PMID: 2106037Feb 1, 1990Paper

Nutritional impact on the energy cost of fat fuel mobilization in polytrauma victims

The Journal of Trauma
M JeevanandamW R Schiller

Abstract

In the "flow" phase of severe injury, mobilization of body fat and protein sources are accelerated to meet increased demands. Fat mobilization usually exceeds the need for oxidative substrates and the leftover fatty acids are re-esterified, resulting in a "futile" TG/FFA cycle. This contributes to increased energy expenditure and provision of nutrients may alter the activity of this cycle. We measured in nine adult (age 40 +/- 7 years, weight, 80 +/- 4 kg) severely traumatized (ISS 32 +/- 4) patients, the resting energy expenditure (REE) and net fat oxidation rate (NFO) by indirect calorimetry and whole body lipolysis rate (WBLR) by a two-stage, primed-constant infusion of glycerol. Fasting postinjury kinetic studies were performed within 48-96 hours after admission when the patients were receiving saline without calories or nitrogen. Glucose-based nutritional therapy was then started and continued for 5 to 7 days. The kinetic measurements were repeated after the nutritive solutions were replaced by normal saline for 12 to 15 hours to achieve a postabsorptive state. Trauma elicits an accelerated rate of fat mobilization with increased TG/FFA cycle activity. Adequate nutritional support for 5 to 7 days tends to reduce but cannot...Continue Reading

Citations

Jul 13, 2002·The Surgical Clinics of North America·Tom Jaksic
Jul 20, 2002·Current Opinion in Pediatrics·Michael S D Agus, Tom Jaksic
Oct 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·O PitkänenA Kari
Apr 29, 2009·JPEN. Journal of Parenteral and Enteral Nutrition·Nilesh M MehtaUNKNOWN A.S.P.E.N. Board of Directors
Nov 23, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Peggy Siu-Pik LeeKin Ip Law
Jul 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·K WaxmanR R Bradford
Oct 1, 1994·The American Journal of Physiology·M Jeevanandam, S R Petersen

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