Nutritional ketosis delays the onset of isoflurane induced anesthesia

BMC Anesthesiology
C AriDominic P D'Agostino

Abstract

Ketogenic diet (KD) and exogenous ketone supplements can evoke sustained ketosis, which may modulate sleep and sleep-like effects. However, no studies have been published examining the effect of ketosis on the onset of general isoflurane induced anesthesia. Therefore, we investigated the effect of the KD and different exogenous ketogenic supplements on the onset of akinesia induced by inhalation of isoflurane. We used a high fat, medium protein and low carbohydrate diet (KD) chronically (10 weeks) in the glucose transporter 1 (GLUT1) deficiency (G1D) syndrome mice model and sub-chronically (7 days) in Sprague-Dawley (SPD) rats. To investigate the effect of exogenous ketone supplements on anesthetic induction we also provided either 1) a standard rodent chow diet (SD) mixed with 20% ketone salt supplement (KS), or 2) SD mixed with 20% ketone ester supplement (KE; 1,3 butanediol-acetoacetate diester) to G1D mice for 10 weeks. Additionally, SPD rats and Wistar Albino Glaxo Rijswijk (WAG/Rij) rats were fed the SD, which was supplemented by oral gavage of KS or KE for 7 days (SPD rats: 5 g/kg body weight/day; WAG/Rij rats: 2.5 g/kg body weight/day). After these treatments (10 weeks for the mice, and 7 days for the rats) isoflurane (...Continue Reading

References

Jul 20, 1979·Science·R A Hawkins, J F Biebuyck
Oct 1, 1990·Acta Anaesthesiologica Scandinavica·O K RoaldP A Steen
Jan 7, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P B Bennett, M McLeod
May 23, 1997·Science·T Porkka-HeiskanenR W McCarley
Oct 19, 2001·Anesthesiology·A J Patel, E Honoré
Nov 24, 2001·Trends in Neurosciences·C B SaperT E Scammell
Oct 24, 2003·Behavior Genetics·A M L Coenen, E L J M Van Luijtelaar
May 18, 2004·Sleep Medicine Reviews·Avery Tung, Wallace B Mendelson
Apr 26, 2005·Neuron·Dario BrambillaRobert Greene
Aug 30, 2005·Trends in Pharmacological Sciences·Hugh C HemmingsNeil L Harrison
Apr 21, 2007·Annual Review of Nutrition·Marc YudkoffItzhak Nissim
Dec 17, 2008·Epilepsia·Charles N Allen
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pavle M JoksovicSlobodan M Todorovic
Mar 16, 2011·Current Topics in Medicinal Chemistry·Zhi-Li HuangOsamu Hayaishi
Mar 16, 2011·Current Topics in Medicinal Chemistry·Zsolt KovácsKatalin A Kékesi
Aug 30, 2011·Epilepsy Research·Tove HallböökBronwen Martin
Nov 2, 2011·Brain Research·Matthias EikermannNancy L Chamberlin
Apr 18, 2012·Frontiers in Pharmacology·Carl E Stafstrom, Jong M Rho
Apr 5, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dominic P D'AgostinoJay B Dean
May 30, 2014·American Journal of Respiratory and Critical Care Medicine·Alfred A Bove
Aug 31, 2014·Progress in Neurobiology·L Stan LeungIan Herrick
Jan 24, 2016·Cold Spring Harbor Perspectives in Medicine·Michael A RogawskiJong M Rho
Sep 15, 2016·Cell Metabolism·Brendan Egan, Dominic P D'Agostino
Nov 9, 2016·Neurochemical Research·Lavanya B Achanta, Caroline D Rae
Dec 22, 2016·Frontiers in Molecular Neuroscience·Csilla AriDominic P D'Agostino

❮ Previous
Next ❯

Methods Mentioned

BETA
medical procedure

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.