Nutritional modulation of ageing: genomic and epigenetic approaches

Mechanisms of Ageing and Development
John C Mathers

Abstract

Dietary factors have a profound effect on many aspects of health including ageing and do so, at least partly, through interactions with the genome which result in altered gene expression. The application of high throughput genomics technologies in nutritional research (nutrigenomics) offers a new approach to understanding the molecular mechanisms by which nutrition affects ageing. To date, transcriptional profiling techniques have been applied in studies of the mode of action of energy (caloric) restriction. Two further areas which appear to be particularly promising are (i) nutritional modulation of DNA damage and repair and (ii) nutritional modulation of epigenetic markings. Epigenetic-mediated changes in gene expression in response to dietary and other lifestyle exposures appear to be a major molecular mechanism linking environmental factors with the genome with consequences for cell function and health throughout the life course.

References

Nov 1, 1989·Journal of Gerontology·L L Mays-Hoopes
Oct 9, 1987·Science·R Holliday
Nov 7, 1980·Science·A Razin, A D Riggs
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·C LengauerB Vogelstein
Feb 13, 1999·Cell·F B JohnsonL Guarente
Jul 11, 2000·Nature Genetics·C K LeeT A Prolla
Sep 27, 2000·Human Molecular Genetics·T H Bestor
Mar 30, 2001·Nature Genetics·E Whitelaw, D I Martin
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·T KayoT A Prolla
Aug 11, 2001·Science·T Jenuwein, C D Allis
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y YatabeD Shibata
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·S X CaoS R Spindler
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hyung-Lyun KangKyung-Tai Min
May 29, 2002·Oncogene·Young R SeoMartin L Smith
Jul 13, 2002·Trends in Biochemical Sciences·Thomas von Zglinicki
Aug 7, 2002·The Journal of Nutrition·Jean-Pierre Issa
Aug 7, 2002·The Journal of Nutrition·J Kevin DayDennis B Lubahn
Oct 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Young R SeoMartin L Smith
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Douglas E Brash, P A Havre
Nov 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cheol-Koo LeeTomas A Prolla
Dec 3, 2002·Current Opinion in Biotechnology·Ben van Ommen, Rob Stierum
Mar 29, 2003·Carcinogenesis·Andrew R CollinsRachel Melvin
Apr 3, 2003·Nature Reviews. Genetics·Michael Müller, Sander Kersten
May 3, 2003·Genome Research·Toshikazu UshijimaKazuaki Miyamoto
May 13, 2003·The Proceedings of the Nutrition Society·Elizabeth A WilliamsJohn C Mathers
Jul 16, 2003·Molecular and Cellular Biology·Robert A Waterland, Randy L Jirtle
Oct 28, 2003·Molecular and Cellular Biochemistry·Mark A CasillasTrygve O Tollefsbol
Oct 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jean-Pierre Issa
Jan 21, 2004·Nature Reviews. Cancer·Andrew P Feinberg, Benjamin Tycko
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joseph M DhahbiStephen R Spindler
Apr 9, 2004·The Proceedings of the Nutrition Society·John C Mathers
May 28, 2004·Nature·Gerda EggerPeter A Jones
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah J ZhangKevin C Kregel
Nov 16, 2004·The Journal of Nutritional Biochemistry·Emily Ho
Feb 1, 2005·The Journal of Nutritional Biochemistry·Anna M OommenJanos Zempleni
Mar 1, 2005·Cell·Thomas B L Kirkwood
Mar 1, 2005·Cell·David B LombardFrederick W Alt

❮ Previous
Next ❯

Citations

Aug 18, 2009·Genes & Nutrition·Doris Stangl, Sandrine Thuret
Aug 8, 2008·The British Journal of Nutrition·Roman ThalerAlexander G Haslberger
Jun 4, 2010·Antioxidants & Redox Signaling·Ursula Muñoz-Najar, John M Sedivy
Jul 27, 2012·British Medical Bulletin·Muhammad Syahrul Anwar Zainuddin, Sandrine Thuret
Mar 16, 2011·Acta Physiologica·J A McKay, J C Mathers
Nov 18, 2011·Pharmacological Reviews·João Pedro de MagalhãesChintan Vora
May 7, 2013·Annual Review of Nutrition·Katherine L TuckerJose M Ordovas
Jul 5, 2008·Annual Review of Nutrition·George C FaheyKelly S Swanson
Apr 29, 2008·Annual Review of Nutrition·Manuela M BergmannJohn C Mathers
Feb 23, 2012·Journal of Nutrigenetics and Nutrigenomics·Karen A Lillycrop, Graham C Burdge
Aug 27, 2011·BMC Medicine·Yuanyuan LiTrygve O Tollefsbol
Mar 13, 2014·PloS One·Sieneke LabruijereAntoinette MaassenVanDenBrink
Apr 25, 2012·Immunity & Ageing : I & a·Alberto MontesantoGiuseppe Passarino
Nov 5, 2013·Critical Reviews in Oncology/hematology·Heidrun KarlicMichael Pfeilstöcker
Jun 15, 2007·Mutation Research·Lynnette R FergusonUNKNOWN Nutrigenomics New Zealand
Feb 28, 2009·Aging Cell·Richard A KerberRichard M Cawthon
Jan 11, 2008·Journal of Viral Hepatitis·P VivekanandanM Torbenson
May 24, 2013·Biochemical Society Transactions·Sanne D van OtterdijkGordon Strathdee
Dec 17, 2009·Neurobiology of Aging·Andreas FahlströmBrun Ulfhake
Apr 18, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Sofia LisantiJohn C Mathers
Oct 24, 2018·Molecular Nutrition & Food Research·Chanachai Sae-LeeHyang-Min Byun
Apr 4, 2007·The British Journal of Nutrition·Peng LiGuoyao Wu
Oct 28, 2014·Mathematical Biosciences and Engineering : MBE·Ruijun Zhao, Jemal Mohammed-Awel
Nov 15, 2016·Molecular Medicine Reports·Qilong ZhongLina Zhang
Mar 22, 2007·The Journal of Nutrition·Susan B Roberts, Dale A Schoeller
Mar 23, 2017·European Journal of Nutrition·Glaucia Carielo LimaMário Roberto Maróstica Junior

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics and Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Related Papers

Trends in Genetics : TIG
Mario F Fraga, Manel Esteller
American Journal of Medical Genetics
B D MitchellA R Shuldiner
© 2021 Meta ULC. All rights reserved