Nutritional modulation of immunity and the inflammatory response

Nutrition
E LinS F Lowry

Abstract

The metabolic derangements of the injured or stressed patient are governed by multiple factors that partially include the severity of insult, preexisting illnesses, available energy reserves, and appropriateness of intervention. The normal response to injury is further characterized by the release of proinflammatory and antiinflammatory mediators that exert potent effects on cellular and organ function. Although brief periods of starvation and catabolism are tolerable in otherwise healthy individuals, protracted nutritional deprivation can manifest as immunocompromise, irreversible organ injury, and late mortality. Moreover, patients with severe injuries or preexisting illnesses who exhibit exaggerated inflammatory responses may be further predisposed to such deleterious consequences following the insult. The optimal supply of appropriate nutrients and substrates in such circumstances has often been championed as a necessary means of restoring proper cellular metabolism, wound healing, immune competence, and proper organ function. However, much debate surrounds the present efficacy of nutritional therapy in modulating the immune response associated with injury and stress. This article seeks to assess the merits of nutritional t...Continue Reading

References

Feb 1, 1992·The Journal of Experimental Medicine·D AderkaD Wallach
Aug 22, 1991·The New England Journal of Medicine·UNKNOWN Veterans Affairs Total Parenteral Nutrition Cooperative Study Group
Mar 19, 1994·Lancet·A MarchantM Goldman
Nov 1, 1994·The Journal of Experimental Medicine·T van der PollS J van Deventer
Mar 1, 1994·The Journal of Infectious Diseases·T van der PollJ W ten Cate
Aug 1, 1993·European Journal of Immunology·H S OldenburgL L Moldawer
May 1, 1996·World Journal of Surgery·X Guirao, S F Lowry
Apr 1, 1997·Immunological Reviews·A M Mowat, J L Viney
May 1, 1997·The Journal of Trauma·J R SaffleR G Barton
Nov 5, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·W S SwailsB R Bistrian
Nov 15, 1997·The British Journal of Surgery·L C LemaireD J Gouma
Dec 24, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·R R van der HulstP B Soeters
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·E LinS F Lowry

❮ Previous
Next ❯

Citations

Jun 11, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Caroline M Pond
Feb 9, 2000·Progress in Lipid Research·C M Pond
Jul 29, 2005·The Proceedings of the Nutrition Society·L GentonP Soeters
Jan 1, 2010·Annals of Nutrition & Metabolism·Kevin D Tipton
Nov 26, 2010·Nutrition Reviews·Niikee SchoendorferPeter S W Davies
Dec 1, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Peter SoetersLubos Sobotka
Nov 11, 2015·Sports Medicine·Kevin D Tipton
Jan 29, 2008·Journal of the American Academy of Dermatology·Margaret A FonderAdam J Mamelak
Sep 2, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michael P Muehlenbein, Richard G Bribiescas
Sep 30, 2020·Journal of Athletic Training·Abbie E Smith-RyanMalia N M Blue
Nov 21, 2002·Critical Care Medicine·Dennis C GoreArthur P Sanford
Aug 24, 2021·The British Journal of Nutrition·Alex GriffithsOliver Michael Shannon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here