Nutritional rehabilitation of skeletal muscle in protein-deprived young rats

Journal of the Neurological Sciences
A Oldfors, P Sourander

Abstract

The effect of severe protein deprivation and subsequent nutritional rehabilitation on the fibre size and mitochondrial enzyme activity of the extensor digitorum longus (EDL) and soleus muscles of the young rat has been examined. Protein deprived rats showed atrophy of type 2 fibres predominantly, reduced histochemical activity of succinic dehydrogenase (SDH) and reduced biochemical activity of citrate synthase. Nutritional rehabilitation indicated by resumption of the original body weight resulted in complete restitution of the weight of the muscles and the size of type 1 and type 2 fibres, but not of the activity of SDH and citrate synthase. The results indicate that regarding size, type 2 fibres tend to be more influenced than type 1 fibres by the nutritional supply. The mitochondrial enzyme activity which is decreased by protein deprivation does not regain the normal levels as quickly as the muscle fibres resume their normal size.

References

May 1, 1985·Journal of the Neurological Sciences·A Oldfors, P Sourander
Sep 1, 1969·European Journal of Biochemistry·A BassD Pette
May 1, 1983·Journal of the Neurological Sciences·A OldforsP Sourander
Aug 1, 1981·Clinical Physiology·B EssénB Saltin
Nov 1, 1962·Journal of Clinical Pathology·R D Montgomery

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Citations

Nov 1, 1994·Alcohol·J C RomeroN Batista
Jun 1, 1992·Drug and Alcohol Dependence·A Conde-MartelT González-Hernández

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