PMID: 5903097Jan 1, 1966

Nutritional requirements of anaerobic spirochetes. I. Demonstration of isobutyrate and bicarbonate as growth factors for a strain of Treponema microdentium

Journal of Bacteriology
P H HARDY, C O Munro

Abstract

Hardy, Paul H., Jr. (The Johns Hopkins University School of Medicine, Baltimore, Md.), and Carole O. Munro. Nutritional requirements of anaerobic spirochetes. I. Demonstration of isobutyrate and bicarbonate as growth factors for a strain of Treponema microdentium. J. Bacteriol. 91:27-32. 1966.-The previously reported ability of a microaerophilic diphtheroid to support the growth of some oral spirochetes resides in the acid-distillable fraction of the culture fluid. This fraction can be replaced by isobutyrate and, to a lesser extent, by 2-methylbutyrate. When media are supplemented with isobutyrate alone, there is a prolonged lag phase before spirochetal growth commences, but when sodium bicarbonate is also added the lag phase is shortened, and both the growth rate and the total yield are increased. Serum, in low concentration, also acts as a growth stimulant, but it is inhibitory when present at higher concentrations.

Citations

Jun 1, 1986·Scandinavian Journal of Dental Research·N E Fiehn, J Westergaard
Apr 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N E Fiehn
Oct 1, 1984·Scandinavian Journal of Dental Research·N E Fiehn, J Westergaard
Oct 1, 1995·Oral Microbiology and Immunology·T KosekiY Benno
Oct 22, 2008·Journal of Bacteriology·Varun MazumdarDaniel Segrè
Mar 16, 2012·Journal of Clinical Periodontology·Purnima S KumarKelly O'Brien
Sep 4, 2018·The Science of the Total Environment·Hu LiYong-Guan Zhu

Related Concepts

Carbonic Acid Ions
butyrate
Saturated Fat
Vestibule of Mouth
Treponema

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.