Nutritional Status and Humoral Immune Response to Plasmodium falciparum in Children Aged 6-59 Months

Journal of Tropical Medicine
Arnaud TepaConstant Anatole Pieme

Abstract

Malaria is a leading cause of morbidity and mortality in Africa. Children are mostly exposed to this disease; numerous studies have investigated the relationship between child malnutrition and either malaria morbidity or infection. Few studies demonstrated the interaction between child malnutrition and specific anti-Plasmodium falciparum immune responses. The purpose of this study was to investigate the impact of nutritional status and iron on total anti-Plasmodium falciparum IgG levels in children living in the Gado-Badzéré refugee camp. We carried out a cross-sectional study during August-November 2017 in the Gado-Badzéré refugee camp in the East region of Cameroon. Children aged from 6 to 59 months with fever were recruited from the medical center. The data were recorded using a standardized data collection sheet and were analyzed using SPSS and WHO Anthro software. The total anti-Pf 3D7 total IgG level was determined using an ELISA technique while a colorimetric method was used to measure the total iron level. A total of 83 patients aged 6-59 months were enrolled in this study. The prevalence of malaria and malnutrition was 47% and 31%, respectively. Acute malnutrition was statistically less recurrent in noninfected childre...Continue Reading

References

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Jul 5, 2002·Clinical Microbiology Reviews·Frederick L Schuster
May 2, 2003·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·S Blair TrujilloUNKNOWN Grupo Malaria
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Oct 28, 2019·Parasites & Vectors·Christophe Antonio-NkondjioCharles S Wondji

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Methods Mentioned

BETA
ELISA

Software Mentioned

WHO Anthro
ANTHRO
ANTHRO PLUS
SPSS
EXCEL

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