Nutritional status and pulmonary outcome in children and young people with cystic fibrosis.

Respiratory Medicine
Niovi PapalexopoulouAnne Greenough

Abstract

Nutrition is closely related to mortality and pulmonary and respiratory muscle function in cystic fibrosis (CF) patients. We initially validated results from a bioelectrical impedance device against dual energy x-ray absorptiometry (DEXA). We then determined whether fat free mass assessed by a portable impedance device rather than body mass index (BMI) better correlated with pulmonary function, respiratory muscle strength and exercise capacity in CF patients. Eighteen young people and adults (median age 19, range 12-39 years) with CF had dual energy X-ray absorptiometry and direct segmental multi-frequency impedance analysis. Body composition, pulmonary function, respiratory muscle function and exercise tolerance using the impedance device were measured in 29 young people with CF with median age 15 (range 12-19) years. There was a significant correlation between impedance and absorptiometry results (r2 = 0.947). Fat free mass correlated with the forced vital capacity z-score (r = 0.442, p = 0.016), maximal inspiratory pressure (r = 0.451, p = 0.014) and exercise tolerance (r = 0. 707, p < 0.001). BMI z-scores did not significantly correlate with pulmonary or respiratory muscle function. Subjects with a fat free mass z-score of ...Continue Reading

Citations

Dec 11, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Elizabeth OwenMary S Fewtrell
Jan 27, 2021·Disability and Rehabilitation·Janaina Cristina ScalcoCamila Isabel Santos Schivinski
Jun 15, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Yann CombretGregory Reychler
Jun 30, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Andrea GranadosAna María Arbeláez
Sep 3, 2021·Physiotherapy Theory and Practice·Juliana CardosoCamilaIsabel Santos Schivinski

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