Nutritional Status is Associated with Inflammation and Predicts a Poor Outcome in Patients with Chronic Heart Failure

Journal of Atherosclerosis and Thrombosis
Akihiro NakagomiWataru Shimizu

Abstract

Malnutrition has been identified to be an independent predictor of morbidity and mortality in patients with chronic heart failure (CHF). However, the pathophysiological mechanisms underlying this pathway remain unclear. Nutritional screening was performed using the controlling nutritional status (CONUT) score, which was calculated using the serum albumin and total cholesterol levels and lymphocyte number, in 114 CHF patients with a mean left ventricular ejection fraction of 26.6%±6.4%. The carotid intima-media thickness (CIMT) is correlated with carotid atherosclerosis and is a significant predictor of future cardiovascular events. Peripheral blood mononuclear cells (PBMCs) were isolated, and the production of monocyte tumor necrosis factor (TNF)-α was measured and expressed as mean±SD (pg/mL/10(6) PBMCs). A multivariate linear regression analysis showed that the production of monocyte TNF-α (β coefficient=0.434, p<0.001) and mean CIMT (β coefficient=0.204, p=0.006) were independent determinants of the CONUT score. During a median follow-up of 67.5 months, 45 patients experienced cardiac events, including 16 cardiac deaths and 29 readmissions for worsening CHF. A multivariate Cox hazard analysis demonstrated that a monocyte TNF...Continue Reading

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Citations

Apr 22, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideki WadaHiroyuki Daida
Apr 25, 2019·Heart Failure Reviews·Anna WawrzeńczykJacek Budzyński
Jul 18, 2020·Annals of Surgical Treatment and Research·Masashi UtsumiKohji Tanakaya
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Feb 26, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lele ChengBolin Li
Jan 21, 2021·Coronary Artery Disease·Ozge KurmusCelal Kervancioglu

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