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Nutritional status modifies pregnane X receptor regulated transcriptome

Scientific Reports

Nov 13, 2019

Fatemeh Hassani-Nezhad-GashtiJukka Hakkola

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Abstract

Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pr...read more

Mentioned in this Paper

Bile Acids
Gene Expression
Genes
Genome
Glucagon
Glucose
Insulin
Ligands
Liver
Laboratory mice
2
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Nutritional status modifies pregnane X receptor regulated transcriptome

Scientific Reports

Nov 13, 2019

Fatemeh Hassani-Nezhad-GashtiJukka Hakkola

PMID: 31723190

DOI: 10.1038/s41598-019-53101-9

Abstract

Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pr...read more

Mentioned in this Paper

Bile Acids
Gene Expression
Genes
Genome
Glucagon
2

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