PMID: 9546031Apr 18, 1998Paper

Nutritional studies of the embryo during early organogenesis with normal embryos and embryos exhibiting yolk sac dysfunction

The Journal of Pediatrics
R L Brent, L B Fawcett

Abstract

In 1961 we reported that heterologous kidney antiserum when injected into pregnant rats resulted in wide spectrum of congenital malformations. Further studies identified that it was the IgG component of the antiserum that was teratogenic and that complement was not necessary to produce the teratogenic effect. Labeled antibody studies demonstrated that the kidney antiserum localized in the kidney and in the visceral yolk sac (VYS) and parietal yolk sac placentas. Preparation of yolk sac (YS) antiserum proved to be more potent than the kidney antiserum. Adsorption studies with VYS and parietal yolk sac antiserum revealed that the site of the teratogenic process was located in the VYS. In vitro embryo culture experiments demonstrated that direct injection of the teratogenic antibody into the amniotic or YS cavity did not injure the embryo, thus indicating that the teratogenic antibody had to come in contact with the absorptive surface of the VYS. Collaboration with Dr. John Lloyd demonstrated that teratogenic antibody interfered with the process of pinocytosis and the delivery of amino acids (AA) to the developing embryo. Our studies into the nature of the source of AA for the embryo indicated that in some instances > 95% of the A...Continue Reading

References

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Citations

Sep 7, 1999·In Vitro Cellular & Developmental Biology. Animal·P A KnepperD G McLone
Aug 10, 2001·Experimental Hematology·J Palis, M C Yoder
Jul 31, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Irene E Zohn, Anjali A Sarkar
Jul 18, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph L JilekCraig Harris
Feb 6, 2015·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Valerie A MarshallEdward W Carney
Nov 18, 2005·Reproductive Toxicology·Robert L Brent
May 27, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sheller ZabihiUlf J Eriksson
Sep 9, 2016·Physiological Reviews·Graham J BurtonKent L Thornburg
Apr 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Junwu Mu, S Lee Adamson
Jul 26, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Marlah Tomboc, Selma Feldman Witchel
Dec 31, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Laura Gruñeiro de PapendieckJ J Heinrich
Jun 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tereza Cindrova-DaviesD Stephen Charnock-Jones

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