PMID: 7931707Oct 1, 1994Paper

Nutritional value and antigenicity of two milk protein hydrolysates in rats and guinea pigs

The Journal of Nutrition
J J BozaA Gil


Two milk protein (whey protein and casein) hydrolysates were obtained by enzymatic hydrolysis. In the casein hydrolysate, an ultrafiltration stage was performed to remove all the peptides with molecular weights > 2500. A nutritional value study of both hydrolysates was undertaken. No differences were found between the native proteins and their enzymatic hydrolysates. Neither the enzymatic hydrolysis nor the heat treatments used affected the nutritional value of the protein sources. The two hydrolysates were studied for antigenic properties. The enzymatic hydrolysis of the whey protein concentrate followed by a thermal treatment at 90 degrees C for 10 min reduced significantly its antigenicity. However, the in vivo allergenicity tests showed some positive reactions in both systemic anaphylaxis and passive cutaneous anaphylaxis. The casein hydrolysate, after being ultrafiltered, was devoid of sensitizing capacity by the oral route and was also ineffective in producing local or systemic anaphylaxis in previously sensitized animals, as shown by in vivo assays.


Feb 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·J BozaA Gil
Jun 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Maria Salete F MartinsClaudia M O Nascimento
May 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·J BozaA Gil
Sep 28, 2004·Journal of Pediatric Gastroenterology and Nutrition·Federico Lara-VillosladaJordi Xaus
Mar 15, 2005·Nutrition Reviews·Shannon WilsonElviragonzalez de Mejia
Sep 8, 2015·Journal of Food Science and Technology·Adil GaniBupinder Singh Khatkar
Jun 29, 2010·Journal of Animal Physiology and Animal Nutrition·L A Rubio, A Clemente
Oct 7, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E M Van HoeyveldE A Stevens
Oct 14, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J J BozaO Ballèvre

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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