Nutritionally mediated programming of the developing immune system.

Advances in Nutrition
Amanda C Palmer

Abstract

A growing body of evidence highlights the importance of a mother's nutrition from preconception through lactation in programming the emerging organ systems and homeostatic pathways of her offspring. The developing immune system may be particularly vulnerable. Indeed, examples of nutrition-mediated immune programming can be found in the literature on intra-uterine growth retardation, maternal micronutrient deficiencies, and infant feeding. Current models of immune ontogeny depict a "layered" expansion of increasingly complex defenses, which may be permanently altered by maternal malnutrition. One programming mechanism involves activation of the maternal hypothalamic-pituitary-adrenal axis in response to nutritional stress. Fetal or neonatal exposure to elevated stress hormones is linked in animal studies to permanent changes in neuroendocrine-immune interactions, with diverse manifestations such as an attenuated inflammatory response or reduced resistance to tumor colonization. Maternal malnutrition may also have a direct influence, as evidenced by nutrient-driven epigenetic changes to developing T regulatory cells and subsequent risk of allergy or asthma. A 3rd programming pathway involves placental or breast milk transfer of m...Continue Reading

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References

Mar 15, 1979·American Journal of Obstetrics and Gynecology·J W JohnsonR Scott
Nov 1, 1979·The Journal of Nutrition·P DePasquale-Jardieu, P J Fraker
Jan 1, 1977·Journal of Medical Primatology·R SawyerJ Anderson
Mar 1, 1977·Acta paediatrica Scandinavica·V ReddyV Jagadeesan
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·S K SobrianL E Burton
Mar 1, 1992·The Journal of Nutrition·R K Chandra
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A B KantorL A Herzenberg
May 4, 1992·Annals of the New York Academy of Sciences·M Elliott, J F Kearney
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·A DhurS Hercberg
Feb 1, 1992·The Journal of Pediatrics·M D DeckerP Palmer
Jan 1, 1991·Advances in Experimental Medicine and Biology·D W Hide
Apr 1, 1991·American Journal of Obstetrics and Gynecology·H Schneider
Oct 1, 1990·The Journal of Experimental Medicine·S R CardingP C Doherty
Jan 1, 1990·Annual Review of Nutrition·C L Keen, M E Gershwin
Jun 17, 1989·BMJ : British Medical Journal·S KoletzkoC Smith
Sep 9, 1989·Lancet·D J BarkerS J Simmonds
Mar 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·A Mittal, B Woodward
Dec 22, 1989·Cell·L A Herzenberg, L A Herzenberg
Jan 1, 1989·Current Opinion in Immunology·G R BurgioL D Notarangelo
Aug 13, 1988·Lancet·M K DavisB I Graubard
Feb 1, 1985·The Journal of Infectious Diseases·C J Harrison, J L Waner
Oct 1, 1988·British Medical Bulletin·A Whitelaw, J Parkin
Apr 1, 1988·Journal of Tropical Pediatrics·M GargK Saha
Jan 1, 1987·Annals of Human Biology·C G VictoraJ U Beria
Aug 1, 1987·Journal of Animal Science·R Machado-NetoS E Curtis
Apr 1, 1986·Pediatric Research·F ForestierY Beuzard
Sep 1, 1985·Acta paediatrica Scandinavica·D I Lewis-JonesC R West
Jan 10, 1985·The New England Journal of Medicine·M C McCormick
Feb 1, 1985·The Journal of Nutrition·B A Kochanowski, A R Sherman

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Citations

Jun 21, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Hanna SchöpperSusanne Huber
Jul 24, 2014·Journal of Developmental Origins of Health and Disease·A J C FulfordA M Prentice
May 16, 2012·Advances in Nutrition·Sharon M DonovanRobert S Chapkin
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Anchalee Prasansuklab, Tewin Tencomnao
Aug 16, 2014·Journal of Reproductive Immunology·Mirja Pagenkemper, Anke Diemert
May 31, 2014·European Child & Adolescent Psychiatry·Roseriet BeijersCarolina de Weerth
Dec 15, 2015·FEMS Microbiology Letters·A GuriV Delcenserie
Oct 12, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ketil StørdalLars C Stene
Feb 14, 2013·Cancer Epidemiology·David J P BarkerJohan G Eriksson
Dec 15, 2015·European Journal of Nutrition·Thacianna Barreto Da CostaCélia Maria Machado Barbosa De Castro
Aug 19, 2015·Journal of Developmental Origins of Health and Disease·A C PalmerK P West
Mar 24, 2016·Microbial Pathogenesis·Thacianna Barreto Da CostaCélia Maria M B De Castro
Apr 12, 2016·Frontiers in Immunology·Christine G ParksDale P Sandler
Nov 11, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Manuela Ferreira, Henrique Veiga-Fernandes
Mar 12, 2013·Vaccine·Marta Sanz-RamosUNKNOWN CIGNIS study team
Apr 24, 2015·The British Journal of Nutrition·Neele S DellschaftCatherine J Field
May 3, 2015·The Journal of Infection·Anu Goenka, Tobias R Kollmann
Jun 19, 2014·Acta Microbiologica Et Immunologica Hungarica·György Csaba
Feb 3, 2015·Journal of Reproductive Immunology·Isabel HartwigPetra Arck
Sep 24, 2014·The Journal of Infection·Stuart PaynterPhilip Weinstein
Sep 25, 2014·Frontiers in Immunology·Marie-Claire ArrietaBrett Finlay
Oct 14, 2014·Frontiers in Immunology·Duncan M MacGillivray, Tobias R Kollmann
Jan 27, 2015·Frontiers in Molecular Neuroscience·Lianne HoeijmakersAniko Korosi
Apr 27, 2016·Seminars in Immunology·Anette ChristNiels P Riksen
Jun 14, 2016·Mediators of Inflammation·Enrique Segura-CervantesNorma Galindo-Sevilla
May 31, 2016·Trends in Immunology·Claire D BourkeAndrew J Prendergast
Jun 14, 2016·Cancer Causes & Control : CCC·Amanda W SingerCatherine Metayer
Sep 12, 2016·Trends in Molecular Medicine·Pamela M Odorizzi, Margaret E Feeney
Oct 27, 2015·Trends in Immunology·Eva S Gollwitzer, Benjamin J Marsland
Sep 21, 2016·BMC Medicine·Holger W UngerStephen J Rogerson
Sep 23, 2016·Proceedings. Biological Sciences·Andreas BerghänelJulia Ostner
Oct 22, 2016·The British Journal of Nutrition·Amanda W SingerCatherine Metayer
Jun 13, 2017·Nature Reviews. Immunology·Andrew J MacphersonStephanie C Ganal-Vonarburg

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