PMID: 2505677Oct 1, 1989Paper

Nutritionally triggered alterations in the regiospecificity of arachidonic acid oxygenation by rat liver microsomal cytochrome P450

Archives of Biochemistry and Biophysics
M OrellanaL Gil

Abstract

Cytochrome P450-dependent oxidation of arachidonic acid was studied in liver microsomes from normal fed, protein-energy malnourished, and refed rats. The overall rate of arachidonic acid oxidation was very similar in microsomes from the three groups, but microsomes from malnourished rats showed a higher turnover rate than microsomes from normal fed and refed rats. The regiospecificity of cytochrome P450 oxidation of arachidonic acid was drastically altered by the animal nutritional status. Thus, protein-energy malnutrition results in a clear stimulation of total omega and omega-1 hydroxylation, concomitant with a marked decrease in olefin epoxidation and allyllic oxidations. These changes, as well as the documented biological activity of some of the cytochrome P450 arachidonate metabolites, suggest that protein-energy deficiency might help to select P450 isozymes which are probably involved in key monooxygenation reactions of physiological substrates.

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Citations

May 1, 1994·Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology·Y Miura, S Oda
Aug 30, 2000·Prostaglandins & Other Lipid Mediators·J H Capdevila, J R Falck
Nov 27, 1999·Molecular Aspects of Medicine·J A Hasler
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Oct 29, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M OrellanaV Guajardo
Jan 1, 1997·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M OrellanaE Valdés
Apr 13, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M Orellana BR Rodrigo
Mar 7, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Myriam OrellanaRamón Rodrigo
May 1, 1991·Food Additives and Contaminants·D V Parke

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