Nutritional/metabolic response in older cancer patients

Nutrition
Astrid M Horstman, Melinda Sheffield-Moore

Abstract

The combination of age-related muscle loss (sarcopenia) and the diagnosis of cancer (and the onset of cachexia) is likely a metabolic challenge that skeletal muscle of older cancer patients is not prepared to handle. Albeit to a smaller extent than healthy older controls, the skeletal muscle of older cancer patients is still acutely anabolic to the provision of amino acids. To provide an anabolic stimulus to skeletal muscle during a time when it is susceptible to an advanced rate of breakdown due to cancer- and tumor-related factors, enhanced intake of protein and amino acid sources might be necessary and should likely be higher than the current US recommended daily intake of 0.8 g protein/kg body weight/day. Future studies should investigate whether the acute effects of amino acids on muscle protein anabolism can be sustained over a longer period of time in the presence of cancer cachexia in older patients.

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Citations

Nov 13, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Mariëlle P K J EngelenNicolaas E P Deutz
Mar 17, 2015·Nutrition·Federico Bozzetti
Mar 17, 2015·Nutrition·Federico Bozzetti
Jan 30, 2018·Oxidative Medicine and Cellular Longevity·Justin P HardeeJames A Carson
Sep 16, 2017·European Journal of Preventive Cardiology·Louise G Shewan
Sep 6, 2018·Nutrition and Cancer·Flore DepeintPhilippe R Pouillart
Sep 16, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F Bozzetti
Sep 9, 2017·Current Oncology Reports·Rishi Jain, Efrat Dotan
Aug 17, 2017·American Journal of Lifestyle Medicine·Justin P HardeeJames A Carson

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