NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge.

Vaccine
Mimi Guebre-XabierGale Smith

Abstract

There is an urgent need for a safe and protective vaccine to control the global spread of SARS-CoV-2 and prevent COVID-19. Here, we report the immunogenicity and protective efficacy of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) produced from the full-length SARS-CoV-2 spike (S) glycoprotein stabilized in the prefusion conformation. Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-M™ adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease. These results support ongoing phase 1/2 clinical studies of the safety and immunogenicity of NVX-CoV2327 vaccine (NCT04368988).

Citations

Dec 4, 2020·Human Vaccines & Immunotherapeutics·Vipin M Vashishtha, Puneet Kumar
Dec 31, 2020·The New England Journal of Medicine·Lindsey R BadenUNKNOWN COVE Study Group
Jan 23, 2021·Advanced Drug Delivery Reviews·Saborni ChakrabortyTaia T Wang
Feb 4, 2021·Signal Transduction and Targeted Therapy·Pengfei JinFengcai Zhu
Dec 20, 2020·Nature Reviews. Immunology·Lianpan Dai, George F Gao
Jan 13, 2021·Vaccines·Birgit M Prüβ
Jan 7, 2021·Military Medical Research·Dan-Dan Li, Qi-Han Li
Feb 18, 2021·Reviews in Medical Virology·Arash ArashkiaUNKNOWN SARS CoV-2 Rapid Response Team of Pasteur Institute of Iran (PII)
Feb 24, 2021·NPJ Vaccines·Nikolaos C KyriakidisEsteban Ortiz Prado
Apr 1, 2021·Journal of Biomaterials Science. Polymer Edition·Md Mohosin Rana
Apr 10, 2021·AAPS PharmSciTech·Khaled AboulFotouhRobert O Williams
Apr 5, 2021·EBioMedicine·Martin S WinklerMarcin F Osuchowski
Dec 3, 2020·Seminars in Immunology·Lilit Grigoryan, Bali Pulendran
Apr 28, 2021·Current Opinion in Virology·Chung-Young Lee, Anice C Lowen
Jun 3, 2021·Vaccines·Jang Hyun Park, Heung Kyu Lee
Jun 17, 2021·Science Immunology·Carolina GarridoSallie R Permar
Jun 29, 2021·Expert Review of Vaccines·Chih-Cheng LaiPo-Ren Hsueh
Jul 20, 2021·Asian Journal of Pharmaceutical Sciences·Yuhua Weng, Yuanyu Huang

❮ Previous
Next ❯

Datasets Mentioned

BETA
MN908947

Methods Mentioned

BETA
ELISA
bronchoalveolar lavage
PCR

Clinical Trials Mentioned

NCT04368988

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.