O- product transfusion, inventory management, and utilization during shortage: the OPTIMUS study

Transfusion
Nancy M DunbarOPTIMUS Study Investigators on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative

Abstract

Despite conservation strategies, shortages of O- red blood cells (RBCs) occur. The goal of this study was to determine how utilization of O- RBCs can be reduced using age- and location-based O+ substitution for routine transfusions in O- patients during O- shortages. Recipient age and ABO and D group were obtained for allogeneic RBC transfusions during the 2016 calendar year from 31 participating centers. ABO and D group of each RBC unit was compared to that of the recipient to determine the number of O- RBC units transfused to all patients, the number of RBC units transfused to O- patients, and the number of O- RBC units transfused to O- patients. O- RBC transfusions to O- patients were further analyzed by patient age and location. The fraction of all transfused RBCs that were O- at the participating centers ranged from 3.0% to 13.9%. The percentage of O- RBCs transfused to O- patients ranged from 36.6% to 93.7%. Hospitals differed in the frequency of issuing O- RBCs for O- patient transfusions (55.9%-100%). Relative to current issuing practice, overall use of O- RBCs could have been reduced by 44.5% if O+ units had been given to all O- patients at least 50 years old, 9.9% for all O- patients at least 80 years old, or 8.7% for...Continue Reading

References

Mar 7, 1970·British Medical Journal·H H GunsonV I Rawlinson
Jun 26, 2003·Transfusion·Christoph FrohnHolger Kirchner
Jan 6, 2006·The Journal of Trauma·Richard P DuttonThomas M Scalea
Aug 24, 2007·Transfusion·Mark H Yazer, Darrell J Triulzi
Apr 22, 2008·Transfusion·Jose R Gonzalez-PorrasMercedes Corral
Nov 17, 2009·Transfusion·Akif AliJukka Rautonen
Aug 26, 2010·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Alexander KatalinicRon Pritzkuleit
Aug 30, 2014·Journal of Pediatric Hematology/oncology·Tina S IpeDavid F Friedman
Dec 3, 2014·Transfusion·Erin Meyer, Lynne Uhl
Jun 25, 2016·Transfusion·Mark H YazerUNKNOWN Biomedical Excellence for Safer Transfusions (BEST) Collaborative
Feb 6, 2017·Transfusion·Rena HiraniDavid O Irving
Feb 7, 2017·Transfusion·Meghan DelaneyUNKNOWN BEST Collaborative
Mar 23, 2017·Vox Sanguinis·R L BartyN M Heddle
Jun 8, 2017·Transfusion·Katherine D EllingsonSridhar V Basavaraju
Jun 8, 2017·Transfusion·Mathew R P SapianoSridhar V Basavaraju
Aug 26, 2017·Transfusion·Michelle P ZellerUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative

❮ Previous
Next ❯

Citations

Jun 6, 2020·Transfusion·Vishesh G ChhibberSherry Shariatmadar
Dec 4, 2019·Anesthesiology·Mark H YazerUNKNOWN Biomedical Excellence for Safer Transfusion Collaborative*
Feb 23, 2020·Transfusion·Mrigender S VirkTho D Pham
Mar 7, 2020·Transfusion·Mathew R P SapianoSridhar V Basavaraju
Feb 1, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M LikerB G Ćepulić
Jun 28, 2018·Transfusion·Robert A DeSimone, Bruce S Sachais
Dec 8, 2021·Transfusion·Tara FrancisRichard R Gammon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.