O antigen and lipid A phosphoryl groups in resistance of Salmonella typhimurium LT-2 to nonoxidative killing in human polymorphonuclear neutrophils.

Infection and Immunity
P StinavageJ K Spitznagel

Abstract

We have compared the intraleukocytic survival of isogenic strains of Salmonella typhimurium, whose outer membrane lipopolysaccharide differed in O antigen and lipid A composition and whose susceptibility to nonoxidative antimicrobial granule proteins of human polymorphonuclear neutrophilis (PMN) could be established. We found that the order of resistance to the bactericidal activity of intact PMN of the three bacterial strains utilized closely resembled their ordered resistance to the purified human cationic antimicrobial 57,000-dalton protein (CAP57). LT-2, a smooth wild-type strain, was far more resistant than SH9178, its rough (Rb LPS) mutant. It was most significant that SH7426, a polymyxin B-resistant pmrA mutant of SH9178, not only was substantially more resistant to CAP57 and to intraphagocytic killing than SH9178 but also came close to being as resistant as LT-2. These experiments confirm earlier work that showed the importance of the glycosyl groups of O antigens of S. typhimurium for their resistance to O2-independent antimicrobial phagocytosis by PMN. The surprising result was that a rough strain, very susceptible to bactericide, became substantially more resistant when a mutation led to its lipid A phosphoryl groups...Continue Reading

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J E GabayC F Nathan

❮ Previous
Next ❯

Citations

Dec 1, 1990·FEMS Microbiology Immunology·A S Cross, N M Kelly
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M Stephen Trent
Mar 25, 2004·Infection and Immunity·María P Jiménez de BagüésJacques Dornand
Jun 13, 2012·Microbiology and Molecular Biology Reviews : MMBR·Crystal L JonesDavid S Weiss
Jan 1, 1996·Critical Reviews in Microbiology·A PrestonM A Apicella
Nov 24, 2004·Infection and Immunity·Miguel A CamposJosé A Bengoechea
Mar 4, 2008·Journal of Bacteriology·Alena SebkovaIvan Rychlik
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gordon R O CampbellGraham C Walker
Feb 1, 2005·FEMS Immunology and Medical Microbiology·Rita TamayoJohn S Gunn
May 25, 2002·Journal of Bacteriology·Igor E BrodskyStanley Falkow
Aug 28, 1998·Microbiology·Ben N FryBernard A M van der Zeijst
Dec 1, 1996·Journal of Bacteriology·F C Soncini, E A Groisman
Sep 1, 1992·Microbiological Reviews·M Vaara
Nov 14, 1997·Infection and Immunity·B D JonesM A Apicella
Nov 26, 1997·Journal of Bacteriology·E A GroismanF C Soncini
Aug 1, 1995·Infection and Immunity·G Martínez de TejadaI Moriyón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.