O-GlcNAc regulates FoxO activation in response to glucose.

The Journal of Biological Chemistry
Michael P HousleyGerald W Hart

Abstract

FoxO proteins are key transcriptional regulators of nutrient homeostasis and stress response. The transcription factor FoxO1 activates expression of gluconeogenic, including phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, and also activates the expression of the oxidative stress response enzymes catalase and manganese superoxide dismutase. Hormonal and stress-dependent regulation of FoxO1 via acetylation, ubiquitination, and phosphorylation, are well established, but FoxOs have not been studied in the context of the glucose-derived O-linked beta-N-acetylglucosamine (O-GlcNAc) modification. Here we show that O-GlcNAc on hepatic FoxO1 is increased in diabetes. Furthermore, O-GlcNAc regulates FoxO1 activation in response to glucose, resulting in the paradoxically increased expression of gluconeogenic genes while concomitantly inducing expression of genes encoding enzymes that detoxify reactive oxygen species. GlcNAcylation of FoxO provides a new mechanism for direct nutrient control of transcription to regulate metabolism and stress response through control of FoxO1 activity.

References

Oct 1, 1992·The Journal of Clinical Investigation·I MagnussonG I Shulman
Feb 1, 1980·European Journal of Biochemistry·M MonsignyF Delmotte
Dec 2, 1993·Nature·C KenyonR Tabtiang
May 1, 1997·Molecular and Cellular Biology·I Han, J E Kudlow
Oct 29, 1997·Molecular and Cellular Biology·M D RoosJ E Kudlow
Jun 8, 1999·The Journal of Biological Chemistry·E D TangK L Guan
May 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·R ShafiJ D Marth
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuji HidakaToshiie Sakata
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Keith VossellerGerald W Hart
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Donald A McClainJohn A Hanover
Jan 9, 2003·The Journal of Biological Chemistry·David R Plas, Craig B Thompson
Mar 7, 2003·Science's STKE : Signal Transduction Knowledge Environment·Hien TranMichael E Greenberg
May 20, 2003·Nature·Pere PuigserverBruce M Spiegelman
Aug 28, 2003·The Journal of Biological Chemistry·Raymond J ClarkWolfgang H Dillmann
Sep 11, 2003·The Journal of Biological Chemistry·Paul DowellM Daniel Lane
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hitomi MatsuzakiAkiyoshi Fukamizu
Dec 17, 2003·Cell·Fengxue ZhangJeffrey E Kudlow
May 13, 2004·The Journal of Biological Chemistry·Natasha E ZacharaGerald W Hart
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·John E P SykaDonald F Hunt
Jul 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·John A HanoverMichael Krause
Oct 20, 2005·Journal of the American Chemical Society·Benjamin J GrossSuzanne Walker
Dec 1, 2005·Science's STKE : Signal Transduction Knowledge Environment·Dona C Love, John A Hanover
Dec 13, 2005·American Journal of Physiology. Cell Physiology·Beth A PotterOra A Weisz
Dec 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Maria G Buse
Nov 23, 2006·Biochimica Et Biophysica Acta·Leann M MikeshDonald F Hunt
Apr 4, 2007·The Journal of Biological Chemistry·Sreenath S AndraliSabire Ozcan
May 25, 2007·Nature Reviews. Molecular Cell Biology·Armando van der Horst, Boudewijn M T Burgering
Jun 19, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jia LiuJohn C Chatham

❮ Previous
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Citations

Jun 6, 2009·Current Diabetes Reports·Danielle N GrossMorris J Birnbaum
Apr 27, 2013·Cell Stress & Chaperones·Jennifer A GrovesNatasha E Zachara
Aug 25, 2009·Nature Immunology·Stephen M Hedrick
Feb 22, 2012·Nature Medicine·Mingjian LuMorris J Birnbaum
Aug 19, 2011·Nature Reviews. Cancer·Chad Slawson, Gerald W Hart
Apr 24, 2012·Nature Reviews. Molecular Cell Biology·John A HanoverDona C Love
Jan 18, 2013·Nature Reviews. Molecular Cell Biology·Astrid Eijkelenboom, Boudewijn M T Burgering
Nov 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Won Ho YangJin Won Cho
May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert J ChalkleyA L Burlingame
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dona C LoveJohn A Hanover
Jun 10, 2009·The Journal of Biological Chemistry·Wagner B DiasGerald W Hart
Nov 26, 2009·The Journal of Biological Chemistry·Elin Holter AnthonisenLine M Grønning-Wang
Jun 25, 2010·The Journal of Biological Chemistry·Rebecca A HaeuslerDomenico Accili
Dec 24, 2008·The Journal of Biological Chemistry·Michael P HousleyGerald W Hart
Jul 10, 2010·Antioxidants & Redox Signaling·Zhiyong Cheng, Morris F White
Jul 14, 2010·Antioxidants & Redox Signaling·Peter Storz
Sep 18, 2012·Antioxidants & Redox Signaling·Paraskevi Charitou, Boudewijn M T Burgering
Jun 15, 2011·Journal of Molecular Cell Biology·Ying ZhaoWei-Guo Zhu
Feb 14, 2012·Genes & Development·Eun Young KimJin Won Cho
May 7, 2013·Annual Review of Nutrition·Michelle R Bond, John A Hanover
Dec 1, 2011·American Journal of Physiology. Endocrinology and Metabolism·Tienian ZhuJiankun Liu
May 1, 2008·American Journal of Physiology. Endocrinology and Metabolism·Ronald J CopelandGerald W Hart
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Boglarka LaczyJohn C Chatham
Jul 24, 2010·Circulation Research·Gladys A NgohSteven P Jones
May 10, 2012·Molecular Endocrinology·Vincenza CifarelliH Henry Dong
Nov 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kaoru SakabeGerald W Hart
Nov 8, 2013·Cellular and Molecular Life Sciences : CMLS·Maaike H Oosterveer, Kristina Schoonjans
Aug 29, 2013·Science Signaling·Parameswaran RamakrishnanDavid Baltimore
Nov 24, 2011·Experimental Diabetes Research·Mi-Young KimYong Ho Ahn
Feb 13, 2010·Annual Review of Physiology·Sarah M Ronnebaum, Cam Patterson
Nov 26, 2009·FEBS Letters·Shiuh-Rong HoAndrew J Paterson
Sep 25, 2015·International Journal of Molecular Sciences·Yun ZhaoDongmei Zhang
Jan 26, 2016·Critical Reviews in Biochemistry and Molecular Biology·Sherket B Peterson, Gerald W Hart

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