O-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor Processes

Frontiers in Oncology
Steffi F Baldini, Tony Lefebvre

Abstract

Cancer cells are characterized by their high capability to proliferate. This imposes an accelerated biosynthesis of membrane compounds to respond to the need for increasing the membrane surface of dividing cells and remodeling the structure of lipid microdomains. Recently, attention has been paid to the upregulation of O-GlcNAcylation processes observed in cancer cells. Although O-GlcNAcylation of lipogenic transcriptional regulators is described in the literature (e.g., FXR, LXR, ChREBP), little is known about the regulation of the enzymes that drive lipogenesis: acetyl co-enzyme A carboxylase and fatty acid synthase (FAS). The expression and catalytic activity of both FAS and O-GlcNAc transferase (OGT) are high in cancer cells but the reciprocal regulation of the two enzymes remains unexplored. In this perspective, we collected data linking FAS and OGT and, in so doing, pave the way for the exploration of the intricate functions of these two actors that play a central role in tumor growth.

References

Nov 26, 1999·Biochimica Et Biophysica Acta·T LefebvreJ C Michalski
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·T KawaguchiK Uyeda
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Johannes V SwinnenGuido Verhoeven
Jan 22, 2003·Journal of Cutaneous Pathology·D InnocenziS Calvieri
Mar 21, 2003·Biochemical and Biophysical Research Communications·Johannes V SwinnenGuido Verhoeven
Feb 24, 1956·Science·O WARBURG
Mar 20, 2004·Traffic·J Bernd Helms, Chiara Zurzolo
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Johannes V SwinnenGuido Verhoeven
Sep 5, 2006·Cancer Research·Carmen PrioloMassimo Loda
Aug 25, 2007·FEBS Letters·Pierre-Damien DenechaudCatherine Postic
Jun 4, 2008·The Journal of Biological Chemistry·Stephen A WhelanGerald W Hart
Jul 19, 2008·Cell Cycle·Dolores Di VizioMichael R Freeman
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zihao WangGerald W Hart
Mar 26, 2009·Journal of the National Cancer Institute·Toshiro MigitaMassimo Loda
Nov 26, 2009·The Journal of Biological Chemistry·Elin Holter AnthonisenLine M Grønning-Wang
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xuemei TongCraig B Thompson
Jul 9, 2010·Cancer Research·Yuchao GuWengong Yu
Oct 12, 2010·The Journal of Biological Chemistry·Osamu SekineJohn A Hanover
Nov 3, 2010·Biochemical and Biophysical Research Communications·Haruhiko SakiyamaKeiichiro Suzuki
Nov 18, 2010·Breast Cancer Research : BCR·Quanri JinFrancisco J Esteva
Jan 25, 2011·Biochimica Et Biophysica Acta·Wenyi MiWengong Yu
Mar 5, 2011·Journal of Cellular Physiology·Tusty-Jiuan HsiehShyi-Jang Shin

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Citations

Jun 3, 2017·Analytical Biochemistry·Suhela SharifRoland J Pieters
Jun 20, 2017·Nature Cell Biology·Ting WangYuhui Jiang
Jul 11, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qi ChengChen-Jie Fang
Jul 26, 2018·International Journal of Molecular Sciences·Su Jin LeeOh-Shin Kwon
Aug 16, 2016·Biochemical and Biophysical Research Communications·Steffi F BaldiniCéline Guinez

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