O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress.

FEBS Letters
Shiuh-Rong HoA J Paterson

Abstract

The FOXO4 transcription factor plays an important role in cell survival in response to oxidative stress. The regulation of FOXO4 is orchestrated by post-translational modifications including phosphorylation, acetylation, and ubiquitination. Here, we demonstrate that O-GlcNAcylation also contributes to the FOXO4-dependent oxidative stress response. We show that hydrogen peroxide treatment of HEK293 cells increases FOXO4 association with OGT, the enzyme that adds O-GlcNAc to proteins, causing FOXO4 O-GlcNAcylation and enhanced transcriptional activity under acute oxidative stress. O-GlcNAcylation is known to be protective for cells under stress conditions, including oxidative stress. Our data provide a mechanism of FOXO4 anti-oxidative protection through O-GlcNAcylation.

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Citations

Jul 10, 2013·Amino Acids·Zhiyuan Ma, Keith Vosseller
Aug 19, 2011·Nature Reviews. Cancer·Chad Slawson, Gerald W Hart
Apr 22, 2011·Trends in Genetics : TIG·Bérénice A BenayounReiner A Veitia
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Jun 28, 2016·Journal of Molecular Biology·Kamau Fahie, Natasha E Zachara
Jun 20, 2017·Free Radical Biology & Medicine·Jeong Woo HanJefferson Y Chan
Mar 17, 2018·Glycobiology·Po-Han ChenMichael Boyce
Jan 11, 2019·The Journal of Biological Chemistry·Gerald W Hart
Oct 26, 2016·Molecular Medicine Reports·Ziyao WangPing Huang
Nov 18, 2011·Pflügers Archiv : European journal of physiology·Ildikò SzabòMario Zoratti
Jun 28, 2016·Oncology Letters·Y U ChengBaodong Liu
Jun 3, 2021·Neurochemical Research·Tarapati RanaSimona Bungau
Oct 6, 2021·The FEBS Journal·Tianshu Gui, Boudewijn M T Burgering

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