o-Hydroxycinnamate for sequential photouncaging of two different functional groups and its application in releasing cosmeceuticals

Organic & Biomolecular Chemistry
Amrita PaulN D Pradeep Singh

Abstract

We demonstrated a new approach for the sequential photouncaging of two different functional groups from o-hydroxycinnamate. The second caged molecule initially remains in the locked state and is released only after attaining its unlocked state upon in situ generation of the second phototrigger, i.e., coumarin, thereby leading to the sequential release of alcohol and carboxylic acid. We have utilised the above strategy for the controlled release of cosmeceutical agents.

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Citations

Aug 7, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·E Abou NakadA Specht
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladislav V SkargaMikhail V Malakhov
Dec 11, 2021·Journal of Medicinal Chemistry·Neelu SinghPijus K Sasmal

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