PMID: 2500362Jun 5, 1989Paper

o-quinone/quinone methide isomerase: a novel enzyme preventing the destruction of self-matter by phenoloxidase-generated quinones during immune response in insects

FEBS Letters
S J Saul, M Sugumaran

Abstract

Melanization and encapsulation of invading foreign organisms observed during the immune response in insects is known to be due to the action of activated phenoloxidase. Phenoloxidase-generated quinones are deposited either directly or after self-polymerization on foreign objects accounting for the observed reactions. Since the reactions of quinones are nonenzymatic, they do not discriminate self from nonself and hence will also destroy self-matter. In this report we present evidence for the presence of a novel quinone/quinone methide isomerase in the hemolymph of Sarcophaga bullata which destroys long-lived quinones and hence acts to protect the self-matter. Quinone methides, formed by the action of this enzyme on physiologically important quinones, being unstable undergo rapid hydration to form nontoxic metabolites.

References

Dec 19, 1962·Biochemical and Biophysical Research Communications·S KAUFMANS FRIEDMAN

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Citations

Jan 1, 1990·Archives of Insect Biochemistry and Physiology·M SugumaranH Dali
Jan 1, 1992·Archives of Insect Biochemistry and Physiology·M SugumaranV Semensi
Jan 1, 1991·Archives of Insect Biochemistry and Physiology·M SugumaranK Nellaiappan
Oct 25, 2016·International Journal of Molecular Sciences·Manickam Sugumaran, Hanine Barek
Sep 23, 2016·International Journal of Molecular Sciences·Manickam Sugumaran
Jan 1, 1990·Archives of Insect Biochemistry and Physiology·M SugumaranH Dali
Feb 19, 2000·Biochemical and Biophysical Research Communications·M Sugumaran, K Nellaiappan
Jul 19, 2000·Archives of Biochemistry and Biophysics·M SugumaranK Valivittan
Feb 1, 1993·Chemico-biological Interactions·D C ThompsonP Moldéus
Jan 9, 1992·Biochimica Et Biophysica Acta·S O AndersenP Roepstorff
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P A Riley
May 15, 1991·Biochemical and Biophysical Research Communications·M Sugumaran, K Nellaiappan
Oct 31, 1991·Biochemical and Biophysical Research Communications·J Li, A J Nappi

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