O2- and NO-sensing mechanism through the DevSR two-component system in Mycobacterium smegmatis.

Journal of Bacteriology
Jin-Mok LeeJeong-Il Oh

Abstract

The DevS histidine kinase of Mycobacterium smegmatis contains tandem GAF domains (GAF-A and GAF-B) in its N-terminal sensory domain. The heme iron of DevS is in the ferrous state when purified and is resistant to autooxidation from a ferrous to a ferric state in the presence of O(2). The redox property of the heme and the results of sequence comparison analysis indicate that DevS of M. smegmatis is more closely related to DosT of Mycobacterium tuberculosis than DevS of M. tuberculosis. The binding of O(2) to the deoxyferrous heme led to a decrease in the autokinase activity of DevS, whereas NO binding did not. The regulation of DevS autokinase activity in response to O(2) and NO was not observed in the DevS derivatives lacking its heme, indicating that the ligand-binding state of the heme plays an important role in the regulation of DevS kinase activity. The redox state of the quinone/quinol pool of the respiratory electron transport chain appears not to be implicated in the regulation of DevS activity. Neither cyclic GMP (cGMP) nor cAMP affected DevS autokinase activity, excluding the possibility that the cyclic nucleotides serve as the effector molecules to modulate DevS kinase activity. The three-dimensional structure of the...Continue Reading

References

Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H CharbonneauJ A Beavo
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S Tabor, C C Richardson
Sep 5, 1993·Journal of Molecular Biology·L Holm, C Sander
Jan 20, 1998·Trends in Biochemical Sciences·L Aravind, C P Ponting
Jul 22, 1998·FEMS Microbiology Letters·T DickB Murugasu-Oei
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·W GongM K Chan
Mar 8, 2000·Biochemistry·V M Delgado-NixonM A Gilles-Gonzalez
Mar 14, 2000·Current Opinion in Cell Biology·S H Soderling, J A Beavo
Aug 16, 2000·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger
Sep 6, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·N DasguptaJ S Tyagi
Sep 7, 2001·Annual Review of Microbiology·L G Wayne, C D Sohaskey
Sep 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sergio E MartinezJoseph A Beavo
Sep 4, 2003·The Journal of Experimental Medicine·Martin I VoskuilGary K Schoolnik
Nov 25, 2003·Nature Structural Biology·Helen BermanHaruki Nakamura
Mar 3, 2004·Molecular Interventions·Sergio E MartinezWim G J Hol
Mar 23, 2004·The Journal of Biological Chemistry·David M RobertsDavid R Sherman
May 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·G N MurshudovE J Dodson
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Roxana MalpicaDimitris Georgellis
Nov 20, 2004·Nature Reviews. Microbiology·Jeffrey Green, Mark S Paget
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Dec 16, 2004·Journal of Inorganic Biochemistry·Marie-Alda Gilles-Gonzalez, Gonzalo Gonzalez
Feb 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sergio E MartinezJürgen U Linder
Jul 23, 2005·IUBMB Life·Surbhi Gupta, Dipankar Chatterji
Oct 11, 2005·Journal of Molecular Biology·Sunita SardiwalSnezana Djordjevic
Jan 13, 2006·The Journal of Biological Chemistry·Lee R SwemCarl E Bauer
Sep 27, 2006·The Journal of Pathology·S AlyS Ehlers
Mar 21, 2007·Biochemistry·Alexandra IoanoviciuPaul R Ortiz de Montellano
Jun 30, 2007·Protein Science : a Publication of the Protein Society·Eduardo Henrique Silva SousaMarie-Alda Gilles-Gonzalez
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ashwani KumarAdrie J C Steyn

❮ Previous
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Citations

Feb 28, 2013·Nature Communications·Jian FengJianru Zuo
Mar 12, 2009·The Journal of Biological Chemistry·Ha Yeon ChoBeom Sik Kang
Feb 2, 2011·Assay and Drug Development Technologies·Deborah MaiAdrie J C Steyn
Jun 3, 2009·Infection and Immunity·Ryan W HonakerMartin I Voskuil
May 24, 2011·Journal of Bacteriology·Anna GerasimovaMikhail S Gelfand
Aug 3, 2010·Journal of Bacteriology·Min-Ju KimJeong-Il Oh
Dec 1, 2011·Microbiology and Molecular Biology Reviews : MMBR·Daniel J BretlThomas C Zahrt
Jul 7, 2009·Annual Review of Microbiology·Rong Gao, Ann M Stock
Feb 28, 2009·Current Opinion in Microbiology·Jeffrey GreenNick E LeBrun
Mar 13, 2010·Current Opinion in Microbiology·Jonah Cheung, Wayne A Hendrickson
Feb 26, 2016·Scientific Reports·Yasuyuki SasakiHirofumi Shoun
Jan 1, 2013·Biosensors·Santhosh Sivaramakrishnan, Paul R Ortiz de Montellano
Aug 4, 2018·Antioxidants & Redox Signaling·Emma SevillaMaría F Fillat
Apr 21, 2019·Applied and Environmental Microbiology·Abhishek Anil Dubey, Vikas Jain
Jun 26, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Luiz G F LopesEduardo H S Sousa
Mar 30, 2013·The Journal of Biological Chemistry·Hazel M Girvan, Andrew W Munro
Apr 4, 2021·Antioxidants·In-Gyun Lee, Bong-Jin Lee
Aug 28, 2021·International Journal of Molecular Sciences·Marta A Silva, Carlos A Salgueiro

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