OA-GL21, a novel bioactive peptide from Odorrana andersonii , accelerated the healing of skin wounds

Bioscience Reports
Wenxin BianXinwang Yang

Abstract

Nowadays, the number of chronic trauma cases caused by a variety of factors such as the world's population-ageing and chronic diseases is increasing steadily, and thus effective treatment for chronic wounds has become a severe clinical challenge, which also burdens the patient both physically and financially. Therefore, it is urgent to develop new drugs to accelerate the healing of wounds. Bioactive peptides, which are relatively low cost, easy to produce, store and transport, have become an excellent choice. In this research, we identified a novel peptide OA-GL21, with an amino acid sequence of 'GLLSGHYGRVVSTQSGHYGRG', from the skin secretions of Odorrana andersonii Our results showed that OA-GL21 exerted the ability to promote wound healing of human keratinocytes (HaCaT) and human fibroblasts in a dose- and time-denpendent manner. However, OA-GL21 had no significant effect on the proliferation of these two cells. Significantly, OA-GL21 showed obvious ability to promote wound healing in the full-thickness skin wound model in dose- and scar-free manners. Further studies showed that OA-GL21 had no direct antibacterial, hemolytic, and acute toxic activity; it had weak antioxidant activities but high stability. In conclusion, this...Continue Reading

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Citations

Jan 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ilaria DemoriElena Grasselli
Mar 8, 2019·Bioscience Reports·Yongli SongXinwang Yang
Nov 22, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ying WangXinwang Yang
Nov 6, 2020·Oxidative Medicine and Cellular Longevity·Raul Santos AlvesReggiani Vilela Gonçalves
Nov 14, 2020·Food & Function·Naixin LiuXinwang Yang
Dec 19, 2018·Journal of Agricultural and Food Chemistry·Naixin LiuXinwang Yang
Jun 17, 2020·Journal of Agricultural and Food Chemistry·Naixin LiuXinwang Yang
Dec 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yang FuXinwang Yang

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Datasets Mentioned

BETA
MG860487

Methods Mentioned

BETA
gel filtration
PCR
Assay

Software Mentioned

GraphPad Prism
ImageJ

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