Oat blue dwarf marafivirus resembles the tymoviruses in sequence, genome organization, and expression strategy

Virology
M C EdwardsJ J Weiland

Abstract

The complete nucleotide sequence and genome organization of oat blue dwarf marafivirus (OBDV) were determined. The 6509 nucleotide RNA genome encodes a putative 227-kDa polyprotein (p227) with sequence motifs similar to the methyltransferase, papain-like protease, helicase, and polymerase motifs present in the nonstructural proteins of other positive strand RNA viruses. The 3' end of the open reading frame (ORF) that encodes p227 (ORF 227) also encodes the two capsid proteins: a 24-kDa capsid protein is presumably cleaved from the p227 polyprotein, whereas the 21-kDa capsid protein appears to be translated from a subgenomic RNA (sgRNA). Encoded amino acid and nucleotide sequence comparisons, as well as the OBDV genome expression strategy, show that OBDV closely resembles the tymoviruses. OBDV differs from the tymoviruses in its general biology, in its lack of a putative movement gene that overlaps the replication-associated genes, and in its fusion of the capsid gene sequences to the major ORF. OBDV also possesses a 3' poly(A) tail, as compared to the tRNA-like structures found in most tymoviral genomes. Due to the strong similarities in genome sequence and expression strategy, OBDV, and presumably the other marafiviruses, shou...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P K Keese, A Gibbs
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A B TrouttG J Nossal
Nov 1, 1992·Virology·N YoshikawaT Takahashi
Feb 1, 1992·The Journal of General Virology·G KadaréA L Haenni
Sep 1, 1991·The Journal of General Virology·E V Koonin
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Nov 11, 1989·Nucleic Acids Research·A E Gorbalenya, E V Koonin
Oct 1, 1986·Analytical Biochemistry·D C TessierT Vernet
Mar 1, 1970·Journal of Molecular Biology·S B Needleman, C D Wunsch
Jan 1, 1993·Critical Reviews in Biochemistry and Molecular Biology·E V Koonin, V V Dolja
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·T W DreherJ M Skuzeski
Mar 1, 1981·Virology·D H Du Plessis, P Smith

❮ Previous
Next ❯

Citations

Oct 24, 2008·Phytopathology·J J BernalE Rodríguez-Cerezo
May 28, 2008·Archives of Virology·Carl SpetzDag-Ragnar Blystad
Sep 29, 2009·Archives of Virology·Sead Sabanadzovic, Nina Abou Ghanem-Sabanadzovic
Mar 13, 2010·Archives of Virology·Michael C Edwards, John J Weiland
Dec 21, 2010·Archives of Virology·Michael C Edwards, John J Weiland
Aug 16, 2011·Virus Research·Toufic ElbeainoGiovanni P Martelli
Nov 17, 2009·Virus Research·Rosemarie W Hammond, John Hammond
Jun 27, 2006·Journal of Hepatology·Cheng Ji, Neil Kaplowitz
Jul 18, 2001·The Journal of General Virology·S SabanadzovicG P Martelli
Feb 5, 2015·Phytopathology·Michael C EdwardsLucy R Stewart
Feb 8, 2014·Virology·Michael C Edwards, John J Weiland
Aug 6, 2008·Annual Review of Phytopathology·Saskia A HogenhoutMargaret G Redinbaugh
Aug 13, 2020·Plant Direct·Sizolwenkosi MlotshwaLucy R Stewart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.