Oats as a Safe Alternative to Triticeae Cereals for People Suffering from Celiac Disease? A Review

Plant Foods for Human Nutrition
Klára KosováVáclav Dvořáček

Abstract

Oats represent a promising alternative to small-grain cereals from Triticeae group (wheat, barley, rye) for persons suffering from any form of gluten intolerance, especially celiac disease (CD), since oat-specific prolamins avenins reveal generally lower gluten content and immunoreactivity. Recent studies on avenin molecular structure revealed large genetic variability in avenin sequences affecting the spectrum of gluten peptides produced by hydrolases in human digestive tract. The aim of the present review is to summarise recent knowledge obtained in laboratory studies focused on the effect of avenin-derived peptides on reactivity of crucial components of human immune system such as dendritic cells (DC) and T-cells. The other part of the review summarises the results of clinical studies with CD patients including oat products in their diet. Since different clinical studies revealed contradictory results regarding potential safety of oats for CD patients, the focus has to be directed at genetic variability in oat avenins. Identification of avenin isoforms with minimum CD immunoreactivity will open up ways leading to designing novel oat cultivars suitable for CD patients. Knowledge on immunoreactivity of gluten peptides together...Continue Reading

References

Jun 1, 1992·Computer Applications in the Biosciences : CABIOS·D T JonesJ M Thornton
Jan 1, 1994·Plant Foods for Human Nutrition·G E Inglett, R K Newman
Oct 19, 1995·The New England Journal of Medicine·E K JanatuinenR J Julkunen
Oct 23, 2003·Gut·K E A LundinK Kett
Nov 5, 2004·PLoS Medicine·Helene Arentz-HansenLudvig M Sollid
Mar 23, 2007·Journal of Gastroenterology and Hepatology·Marco SilanoHugh Cornell
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Marco SilanoMassimo De Vincenzi
Oct 20, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Mohsin RashidConnie Switzer
Jan 29, 2008·Scandinavian Journal of Gastroenterology·Vigdis GuttormsenKnut E A Lundin
May 10, 2008·European Journal of Gastroenterology & Hepatology·Alberto HernandoEnrique Méndez
May 5, 2009·Journal of Pediatric Gastroenterology and Nutrition·Outi KoskinenKatri Kaukinen
May 28, 2009·Analytical Chemistry·Hossam M NassefCiara K O'Sullivan
Jun 25, 2009·Analytical Chemistry·Hossam M NassefClara K O'Sullivan
Feb 8, 2011·Nutrition Reviews·Premysl FricJiri Nevoral
May 28, 2011·Genome Génome / Conseil National De Recherches Canada·Sivakala SatheeskumarStephen J Molnar
Jun 2, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Michael Sai Lai SeyJamie Gregor
Mar 6, 2012·Endocrine, Metabolic & Immune Disorders Drug Targets·Alessandra CamarcaCarmen Gianfrani
Jul 25, 2012·The American Journal of Gastroenterology·Ilus TuireKaukinen Katri
Feb 6, 2013·Clinical and Experimental Immunology·S E J CooperC F Feighery
Nov 10, 2013·Nutrients·Katri KaukinenMarkku Mäki
Nov 19, 2013·European Journal of Nutrition·Marco SilanoPatrizia Restani
Mar 26, 2014·Alimentary Pharmacology & Therapeutics·B TjellströmL Högberg
Nov 12, 2015·World Journal of Gastroenterology : WJG·Isabel CominoCarolina Sousa
Feb 9, 2016·Food & Nutrition Research·Isabel CominoCarolina Sousa
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Jul 23, 2016·Canadian Journal of Gastroenterology & Hepatology·Sébastien La VieilleSamuel Godefroy
Feb 1, 2017·Journal of Agricultural and Food Chemistry·Lora BenoitMansour Samadpour
Sep 16, 2017·Frontiers in Medicine·Valli De ReRenato Cannizzaro
Feb 27, 2018·The Journal of Pediatrics·Elena LionettiCarlo Catassi
Apr 25, 2018·Nanomedicine : Nanotechnology, Biology, and Medicine·M G HerreraV I Dodero
Oct 17, 2019·Frontiers in Pediatrics·Inna Spector CohenRon Shaoul

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Citations

Mar 23, 2021·Current Research in Food Science·Oscar Abel Sánchez-VelázquezAlan Javier Hernández-Álvarez

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