PMID: 9427536Jan 14, 1998Paper

Ob (obese) gene expression and leptin levels in Psammomys obesus

Biochimica Et Biophysica Acta
K WalderG R Collier

Abstract

In this study we investigated ob gene expression and plasma leptin levels in Psammomys obesus (the Israeli Sand Rat), a polygenic animal model of obesity and non-insulin-dependent diabetes mellitus. The ob gene was expressed exclusively in adipocytes of Psammomys obesus. DNA sequencing revealed a high degree of homology with other species (90% with mouse, 88% with rat and 79% with human). No ob gene sequence differences were found between lean and obese Psammomys obesus, and the codon 105 mutation found in ob/ob mice was not detected. Ob gene expression in Psammomys obesus correlated with body weight (r = 0.436, p < 0.001), percent body fat (r = 0.645, p < 0.001) and plasma insulin concentration (r = 0.651, p < 0.001). This is the first time that ob gene expression has been shown to increase steadily over a continuous wide range of body weight or plasma insulin in an animal model of obesity. Ob gene expression was significantly elevated in obese compared with lean Psammomys obesus (p < 0.05). No significant difference in ob gene expression was found between the four adipose tissue depots tested. Psammomys obesus plasma leptin levels correlated with body weight (r = 0.36, p < 0.05), percent body fat (r = 0.702, p < 0.01) and pla...Continue Reading

References

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Citations

Jun 8, 2000·Annals of the New York Academy of Sciences·P ZimmetM de Courten
Sep 11, 1999·General and Comparative Endocrinology·M Friedman-EinatP J Sharp
Apr 18, 2014·The Journal of Endocrinology·Lauren E MacDonaldNicholas J Bernier
Jun 25, 2002·Annals of the New York Academy of Sciences·Greg CollierGuy Augert

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