Obese-insulin resistance accelerates and aggravates cardiometabolic disorders and cardiac mitochondrial dysfunction in estrogen-deprived female rats

Age
Sivaporn SivasinprasasnNipon Chattipakorn

Abstract

Women have a lower incidence of cardiovascular diseases (CVD) than men at a similar age but have an increased incidence of CVD and metabolic syndrome after menopause, indicating the possible protective effects of estrogen on cardiometabolic function. Although obesity is known to increase CVD risks, its impact on the heart on estrogen deprivation is still inconclusive. We investigated the effects of obese-insulin resistance on cardiometabolic function in estrogen-deprived ovariectomized rats. Adult female ovariectomized (O) or sham (S)-operated rats randomly received either normal diet (ND, 19.77 % fat) or high-fat diet (HF, 57.60 % fat) (n = 6/group) for 12 weeks. The heart rate variability (HRV), left ventricular (LV) performance, cardiac autonomic balance, cardiac mitochondrial function, metabolic parameters, oxidative stress, and apoptotic markers were determined at 4, 8, and 12 weeks. Insulin resistance developed at week 8 in NDO, HFS, and HFO rats as indicated by increased plasma insulin and HOMA index. However, only HFO rats had elevated plasma cholesterol level at week 8, whereas HFS rats had showed elevation at week 12. In addition, only HFO rats had depressed HRV, impaired LV performance indicated by decreased fraction...Continue Reading

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Citations

Aug 5, 2015·Physiology & Behavior·Dieferson da Costa EstrelaGuilherme Malafaia
Mar 24, 2016·The Journal of Endocrinology·Wanpitak PongkanNipon Chattipakorn
Feb 9, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jitjiroj IttichaicharoenSiriporn C Chattipakorn
May 29, 2018·The European Journal of Neuroscience·Tercya Lucidi Araujo SilvaClaudia Jacques Lagranha
Nov 13, 2018·Journal of Cellular Physiology·Siripong PaleeNipon Chattipakorn
Jul 12, 2018·Menopause : the Journal of the North American Menopause Society·Wissuta SuthamSiriporn C Chattipakorn
Nov 14, 2018·Canadian Journal of Physiology and Pharmacology·Lawrence A OlatunjiAyodele O Soladoye
Dec 7, 2019·Clinical Science·Chayodom ManeechoteNipon Chattipakorn
Jul 4, 2018·Oxidative Medicine and Cellular Longevity·Maria ZychJoanna Folwarczna
Jul 25, 2019·Current Pharmaceutical Design·Rajeev TaliyanViolina Kakoty
Aug 28, 2020·Molecular and Cellular Biochemistry·Jml Medina-ContrerasJ Balderas-Villalobos
Sep 20, 2017·Bioscience Reports·Nattayaporn ApaijaiNipon Chattipakorn
Apr 18, 2017·Methodist DeBakey Cardiovascular Journal·Shumin Li, Anisha A Gupte

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