Obesity aggravates toxic effect of BPA on spermatogenesis

Environment International
Weiyue HuXinru Wang

Abstract

Both bisphenol A (BPA) and obesity affect male reproductive system. However, whether there is an interaction between them remains poorly understood. The aim of the present study was to evaluate the interaction between BPA exposure and obesity on semen quality and elucidate the mechanism in humans and animals. We firstly analyzed the interaction on semen volume, sperm count per ejaculate, sperm concentration and sperm motility in 357 men, and found that urinary BPA concentration was significantly correlated with sperm count per ejaculate in obese men (β=-34.62; 95% CI: -60.75, -8.48; P=0.01). Then we validated the interaction using lean and obese mice with administration of BPA. Significant interactions between BPA exposure and obesity on sperm count and sperm concentration was observed in mice. Finally, we conducted metabolomics analyses to identify metabolites related to the interaction. Metabolites related to the interaction, including capric acid, dodecanoic acid, l-palmitoylcarnitine, niacinamide, etc., are known to play critical roles in fatty acid oxidation and tricarboxylic acid cycle indicating increased oxidative stress associated with male reproductive dysfunction. Thus, our study finds an interaction between BPA expo...Continue Reading

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Citations

Nov 30, 2018·International Journal of Environmental Research and Public Health·Kun ZhouYankai Xia
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Mu WangShunqing Xu
Jul 21, 2020·Reproductive Medicine and Biology·Aditi SharmaSuks Minhas
Jul 7, 2018·Environmental Science and Pollution Research International·Yunbo ZhangXiaolin Na
Jun 30, 2021·Arhiv za higijenu rada i toksikologiju·Tihana MarićAnna Aghayanian

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