PMID: 9177115May 1, 1997Paper

Obesity, alcohol consumption, smoking, and mortality

Annals of Epidemiology
P H ChyouA M Nomura

Abstract

The goals of this study were to assess prospectively the impact of obesity, alcohol use, and smoking on total mortality and to test the etiologic hypothesis that subjects with two or more of these risk factors may experience an elevated risk of overall mortality. Information on body mass index (BMI), alcohol intake, cigarette smoking, and other life-style factors was obtained from a cohort of 8006 Japanese-American men living in Hawaii. They were between 45 and 68 years of age at the initial examination (1965-1968). After 22 years of follow-up that included nearly 159,000 person-years of observation, 2667 deaths from all causes were identified. There was a significant quadratic (J-shaped) relation between BMI and overall mortality. A weaker J-shaped pattern in risk was also present for the intake of alcohol. A strong positive association was observed with pack-years of cigarette smoking. A synergistic interaction between BMI and alcohol was statistically significant (P = 0.0017). Specifically, men who had the lowest body mass (BMI < 21.21 kg/m2) and drank moderately to heavily (> or = 25 oz/mo) experienced a 63% excess risk (relative risk, 1.63; 95% confidence interval; 1.33 - 1.99) compared to a reference group composed of men...Continue Reading

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Citations

Apr 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M G JainR G Ferrence
May 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·T RantanenJ M Guralnik
Feb 3, 2000·Alcoholism, Clinical and Experimental Research·D A Dawson
May 18, 2004·Journal of Epidemiology·Shinichi KuriyamaShigeru Hisamichi
Oct 26, 2005·Gaceta sanitaria·Iñaki GalánBelén Zorrilla
Oct 19, 2006·American Journal of Preventive Medicine·D Michal FreedmanElaine Ron
Nov 1, 2005·Alcohol·Joseph H SissonDavid M Mannino
Jan 2, 2013·Preventive Medicine·Jiemin MaElizabeth M Ward
May 31, 2003·Stroke; a Journal of Cerebral Circulation·Seung-Han SukUNKNOWN Northern Manhattan Stroke Study
Jul 14, 2000·Critical Reviews in Clinical Laboratory Sciences·K A MeisterR Kava
Jan 1, 2014·Journal of Nutritional Science and Vitaminology·Aimi OsakiNorihisa Kato
Mar 25, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kisha I CoaAnnette Kaufman
Dec 11, 1999·Medicine and Science in Sports and Exercise·J C SeidellR T Hoogeveen
Jul 29, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julia MeyerUNKNOWN Swiss National Cohort Study Group

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