Obesity among outpatients with major depressive disorder

The International Journal of Neuropsychopharmacology
George I PapakostasMaurizio Fava

Abstract

Studies focusing on the prevalence of obesity in Major Depressive Disorder (MDD), or the impact of excess body fat on the treatment of MDD are lacking. The aim of the present work is to systematically study obesity in MDD outpatients. A total of 369 MDD outpatients enrolled in an 8-wk trial of 20 mg fluoxetine had height and weight measured at baseline. We then examined: (1) the prevalence of being overweight or obese, (2) the relationship between obesity and a number of demographic and clinical variables, and, (3) the relationship between relative body weight and obesity with clinical response. We found that more than 50% of patients were overweight [body mass index (BMI) > or =2 5 kg/m2], while 20% were obese (BMI > or = 30 kg/m2). Obese patients presented with worse somatic well-being scores than non-obese MDD patients, but they did not differ with respect to depression severity, anxiety, somatic complaints, hopelessness or hostility. Greater relative body weight, but not obesity, predicted non-response. In conclusion, greater relative body weight was found to place MDD outpatients at risk for fluoxetine resistance.

Citations

Jan 14, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M MurphyA M Sobol
Nov 5, 2010·International Review of Psychiatry·Robert Keers, Katherine J Aitchison
Jan 16, 2016·International Journal of Molecular Sciences·Young Sup WooWon-Myong Bahk
Dec 2, 2008·Expert Opinion on Drug Metabolism & Toxicology·Philip Gerretsen, Bruce G Pollock
Dec 29, 2015·Current Medical Research and Opinion·Roger S McIntyreMatthieu Boucher
Mar 3, 2009·Journal of Affective Disorders·Lana J WilliamsMichael Berk
Mar 10, 2009·Journal of Affective Disorders·Rudolf UherAnne Farmer
Aug 2, 2008·Psychoneuroendocrinology·Mattias MånssonMikael Landén
Jan 24, 2007·Biological Psychiatry·Stefan KloiberSusanne Lucae
Oct 2, 2015·Journal of Psychiatric Research·Richard C SheltonGeorge I Papakostas
Oct 14, 2006·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L J EllsC D Summerbell
Jul 18, 2009·The International Journal of Eating Disorders·Marsha D Marcus, Jennifer E Wildes
Sep 1, 2015·Clinical Therapeutics·Nicole L Mihalopoulos, Michael G Spigarelli
Jan 15, 2015·Neuropharmacology·Argel Aguilar-VallesGiamal N Luheshi
Jan 13, 2015·Neuroscience and Biobehavioral Reviews·Rodrigo B MansurRoger S McIntyre
May 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adrian L Lopresti, Peter D Drummond
Aug 19, 2010·The International Journal of Neuropsychopharmacology·Rudolf UherAnne Farmer
May 12, 2016·Cancer Causes & Control : CCC·Katherine W ReevesSusan E Hankinson
Oct 17, 2015·British Journal of Pharmacology·Juliane ZemdegsBruno P Guiard
Aug 9, 2016·Obesity Research & Clinical Practice·Nattinee JantaratnotaiRoger S McIntyre
Nov 26, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ipek PercinelSukran Darcan
Jun 27, 2013·Journal of Primary Care & Community Health·Kurt B AngstmanPaul M Altrichter
Feb 14, 2012·Neuroendocrinology·Brigitte M SondermeijerMireille J Serlie
Mar 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Igor ElmanScott E Lukas
Jun 13, 2019·Acta Neuropsychiatrica·Brian E Leonard, Gregers Wegener
Oct 16, 2019·The Cochrane Database of Systematic Reviews·Aurora E Serralde-ZúñigaGuillermo Melendez
Dec 14, 2019·Journal of Clinical Psychopharmacology·Roman M DaleNicolas R Thompson
Mar 12, 2020·Psychiatry Investigation·Giampaolo PernaDaniela Caldirola
Nov 20, 2015·International Clinical Psychopharmacology·Marlene P FreemanAdam Ruth
Nov 23, 2011·Therapeutic Drug Monitoring·Stefan UntereckerBruno Pfuhlmann
May 12, 2019·Translational Psychiatry·Eirini VagenaGeorge S Baillie
Dec 13, 2016·Psychological Medicine·R M MarijnissenR C Oude Voshaar
Sep 11, 2020·Therapeutic Drug Monitoring·Bodo WarringsMaike Scherf-Clavel
Mar 19, 2021·Psychological Medicine·Anna P McLaughlinValeria Mondelli
Mar 28, 2021·The Journal of Pharmacy and Pharmacology·Izolene Corrêa VelosoEduardo Luiz Gasnhar Moreira
Apr 22, 2021·Archives of Women's Mental Health·Ingrid BaldiniDebora Estadella

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.