Obesity and accumulation of subcutaneous adipose tissue are poor prognostic factors in patients with alcoholic liver cirrhosis

PloS One
Akira SakamakiShuji Terai

Abstract

In alcoholic liver cirrhosis (LC) patients, obesity has become a problem that progresses into liver dysfunction. Herein, we investigated the relationship between the prognosis of steatohepatitis and body weight, along with fat accumulation in patients with alcoholic LC. We conducted a single-center retrospective study, enrolled 104 alcoholic LC patients without hepatocellular carcinoma (HCC) based on histological and clinical evidence, and investigated factors related to poor prognosis using multivariate Cox regression and cluster analyses. Cox regression analysis revealed three independent relevant factors: subcutaneous adipose tissue (SAT) index (median 34.8 cm2/m2, P = 0.009, hazard ratio [HR] 1.017, 95% confidence interval [CI] 1.004-1.030), total bilirubin level (median 1.7 mg/dL, P = 0.003, HR 1.129, 95% CI 1.042-1.223), and prothrombin time value (median 64%, P = 0.007, HR 0.967, 95% CI 0.943-0.991). In the cluster analysis, we categorized the patients into three groups: no adipose tissue accumulation (NAT group), SAT prior accumulation (SAT group), and visceral adipose tissue prior accumulation (VAT group). The results of the three groups revealed that the SAT group displayed a significantly poor prognosis of the Kaplan...Continue Reading

References

Nov 1, 1982·Journal of Cardiovascular Pharmacology·J K HorakR T Solis
Nov 7, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Examination Committee of Criteria for 'Obesity Disease' in Japan, UNKNOWN Japan Society for the Study of Obesity
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Dylan W de LangeAlbert van de Wiel
Oct 13, 2006·Gastroenterology·Winston DunnVijay H Shah
Jan 16, 2008·Clinical Neurology and Neurosurgery·Hsin-Hung HuangTsai-Yuan Hsieh
May 6, 2008·Nature·Kirsty L SpaldingPeter Arner
Sep 19, 2009·World Journal of Gastroenterology : WJG·Chiyo SugiyamaKeigo Yasuda
Nov 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Herbert Tilg, Alexander R Moschen
Jan 17, 2012·The British Journal of Surgery·M G van VledderJ N M Ijzermans
Sep 18, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alejo ManceboManuel Rodríguez
Oct 4, 2012·The American Journal of Gastroenterology·Winston DunnSteven A Weinman
Apr 16, 2013·Cell Metabolism·Tamara TchkoniaJames L Kirkland
Jun 12, 2013·The American Journal of Gastroenterology·Tania M WelzelKatherine A McGlynn
Dec 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip J JohnsonHidenori Toyoda
Feb 18, 2015·Lancet·Daniel P WebsterGeoffrey M Dusheiko
Jun 4, 2016·Nature Reviews. Drug Discovery·Christine M KusminskiPhilipp E Scherer
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
May 2, 2018·Journal of Hepatology·Maryam EbadiAldo J Montano-Loza
Aug 10, 2018·Journal of Hepatology·Nathalie Ganne-CarriéUNKNOWN for CIRRAL Group
Nov 21, 2018·Clinics in Liver Disease·Brett StyskelFasiha Kanwal
Dec 1, 2018·Journal of Gastroenterology·Ryosuke TateishiKazuhiko Koike
May 23, 2019·Annals of Hepatology·Octavio Campollo

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Citations

Mar 7, 2021·International Journal of Molecular Sciences·Hiroki NishikawaHiroko Iijima
Jul 16, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Chisato SaekiAkihito Tsubota

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