Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis.

Pflügers Archiv : European journal of physiology
Matthias Barton

Abstract

Endothelial cells are both the source and target of factors contributing to atherosclerosis. After the discovery of the endothelium-derived relaxing factor (EDRF) by Robert F. Furchgott in 1980 it soon became clear that endothelial cells also release vasoactive factors distinct from nitric oxide (NO) namely, endothelium-derived contracting factors (EDCF) as well as hyperpolarizing factors (EDHF). Vasoactive factors derived from endothelial cells include NO/EDRF, reactive oxygen species, endothelins and angiotensins which have either EDRF or EDCF functions, cyclooxygenase-derived EDCFs and EDRFs, and EDHFs. Endothelial factors are formed by enzymes such as NO synthase, cyclooxygenase, converting enyzmes, NADPH oxidases, and epoxigenases, among others, and participate in the regulation of vascular homeostasis under physiological conditions; however, their abnormal regulation due to endothelial cell dysfunction contributes to disease processes such as atherosclerosis, arterial hypertension, and renal disease. Because of recent changes in world demographics and the declining health status of the world's population, both aging and obesity as independent risk factors for atherosclerosis-related diseases such as coronary artery diseas...Continue Reading

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Citations

Apr 23, 2013·European Journal of Applied Physiology·Stefano LazzerBruno Grassi
Feb 4, 2012·Acta Pharmacologica Sinica·Matthias Barton
Oct 7, 2011·Clinical and Experimental Pharmacology & Physiology·Jerzy Bełtowski
Nov 24, 2011·Advances in Pharmacological Sciences·Takayuki MatsumotoR Clinton Webb
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May 12, 2011·British Journal of Pharmacology·Matthias BartonMatthias R Meyer
Sep 23, 2014·Life Sciences·Matthias Barton
Mar 1, 2015·Pflügers Archiv : European journal of physiology·Trevor HardiganMaria Alicia Carrillo-Sepulveda
Jun 8, 2013·Current Opinion in Pharmacology·Matthias Barton
Jun 1, 2013·Current Opinion in Pharmacology·Matthias Barton
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Mar 15, 2015·Trends in Endocrinology and Metabolism : TEM·Matthias Barton, Eric R Prossnitz
Aug 14, 2013·Journal of Molecular and Cellular Cardiology·Xiaodong SunYang Zhang
Apr 28, 2016·The Canadian Journal of Cardiology·Matthias BartonMatthias R Meyer
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Aug 14, 2019·American Journal of Physiology. Endocrinology and Metabolism·Francesca SchinzariCarmine Cardillo
Nov 5, 2019·Hypertension·Matthias Barton, Masashi Yanagisawa
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Apr 18, 2020·American Journal of Hypertension·Takayuki MatsumotoTsuneo Kobayashi

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