Obesity and airway responsiveness: role of TNFR2.

Pulmonary Pharmacology & Therapeutics
Alison Suzanne WilliamsStephanie A Shore

Abstract

Obese mice exhibit innate airway hyperresponsiveness (AHR), a feature of asthma. Tumor necrosis factor alpha (TNFα) is implicated in the disease progression and chronic inflammatory status of both obesity and asthma. TNF acts via two TNF receptors, TNFR1 and TNFR2. To examine the role of TNFR2 in the AHR observed in obese mice, we generated obese Cpe(fat) mice that were either sufficient or deficient in TNFR2 (Cpe(fat) and Cpe(fat)/TNFR2(-/-) mice, respectively) and compared them with their lean controls (WT and TNFR2(-/-) mice). Compared to WT mice, Cpe(fat) mice exhibited AHR to aerosolized methacholine (measured using the forced oscillation technique) which was ablated in Cpe(fat)/TNFR2(-/-) mice. Bioplex or ELISA assay indicated significant increases in serum leptin, G-CSF, IL-7, IL-17A, TNFα, and KC in obese versus lean mice, as well as significant obesity-related increases in bronchoalveolar lavage fluid (BALF) G-CSF and IP-10, regardless of TNFR2 status. Importantly, BALF IL-17A was significantly increased over lean controls in Cpe(fat) but not Cpe(fat)/TNFR2(-/-) mice. Functional annotation clustering of significantly affected genes identified from microarray analysis comparing gene expression in lungs of Cpe(fat) and W...Continue Reading

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Citations

Jul 11, 2013·Journal of Allergy·Ulaganathan Mabalirajan, Balaram Ghosh
Feb 26, 2013·Environmental Health Perspectives·Alison Suzanne WilliamsStephanie Ann Shore
Apr 27, 2013·Current Allergy and Asthma Reports·Shyamala PradeepanAnne E Dixon
Apr 4, 2013·Pulmonary Pharmacology & Therapeutics·Anne E DixonBenjamin T Suratt
Jan 1, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Mark Bazett, Christina K Haston
Oct 18, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·David I KasaharaStephanie A Shore
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Feb 18, 2016·American Journal of Respiratory Cell and Molecular Biology·Anne E Dixon, Matthew E Poynter
Jul 5, 2016·Pharmacology & Therapeutics·Linda SwedinMatthew C Catley
May 7, 2013·Respiratory Medicine·Zarqa Ali, Charlotte Suppli Ulrik
Jul 11, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul H DahmRichard A Johnston
Apr 29, 2015·Expert Review of Clinical Immunology·Jennifer L AtherAnne E Dixon
Apr 5, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alison Suzanne WilliamsStephanie Ann Shore
Sep 24, 2019·Physiological Reports·Ross S OsgoodStephanie A Shore
Nov 26, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D I KasaharaS A Shore
Sep 29, 2017·American Journal of Respiratory Cell and Molecular Biology·Joel A MathewsStephanie A Shore
Feb 19, 2016·Physiology·Youngji Cho, Stephanie A Shore
Aug 12, 2017·Journal of Applied Physiology·Jason H T Bates
Jan 26, 2020·Physiological Reports·Traci A BrownStephanie A Shore
Apr 25, 2020·Respiratory Research·David I Kasahara, Stephanie A Shore
Jan 10, 2021·Journal of Clinical Medicine·Marina BantulàCésar Picado
Apr 8, 2020·Paediatric Respiratory Reviews·Laura ChenDeepa Rastogi

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