Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Rohit LoombaChien-Jen Chen

Abstract

Body mass index (BMI) and alcohol use are risk factors for hepatocellular carcinoma (HCC). We performed a prospective study to determine if these factors have synergistic effects on HCC risk. Over 14 years, we followed up 2260 Taiwanese men from the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus (REVEAL-HBV) Study Cohort who tested positive for the hepatitis B surface antigen (mean age, 46 ± 10 y; mean BMI, 24 ± 3 kg/m(2)); 20% reported alcohol use. Incident HCC cases were identified via linkage to the national cancer registry. Multivariate-adjusted hazard ratio (HR) and 95% confidence interval (CI) were estimated using Cox-proportional hazards models. In univariate analysis, the interaction between BMI and alcohol predicted incident HCC (P = .029). Alcohol use and extreme obesity (BMI ≥30 kg/m(2)) had synergistic effects on the risk of incident HCC in analyses adjusted for age (HR, 3.41; 95% CI, 1.25-9.27; P < .025) and multivariables (HR, 3.40; 95% CI, 1.24-9.34; P < .025). The relative risk estimate for the interaction and the attributable proportion from the interaction and synergy index were 1.59, 0.52, and 4.40, respectively; these indicate a multiplicative interaction betwee...Continue Reading

References

Jun 1, 1993·Journal of Clinical Ultrasound : JCU·D Y LinY F Liaw
Nov 23, 2000·Archives of Internal Medicine·H B El-Serag, A C Mason
Jul 19, 2002·The New England Journal of Medicine·Hwai-I YangUNKNOWN Taiwan Community-Based Cancer Screening Project Group
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
Nov 19, 2003·Annals of Internal Medicine·Hashem B El-SeragKatherine A McGlynn
Dec 17, 2004·Journal of the National Cancer Institute·Sun Ha JeeJonathan M Samet
Jan 25, 2005·Journal of Hepatology·Jorge A MarreroAnna S Lok
Dec 14, 2005·Alcoholism, Clinical and Experimental Research·Sören V Siegmund, David A Brenner
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Feb 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vishnudutt Purohit, David A Brenner
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
Nov 6, 2007·Clinics in Liver Disease·Chien-Jen ChenHwai-I Yang
Feb 12, 2008·Trends in Molecular Medicine·Willscott E Naugler, Michael Karin
Feb 20, 2009·Journal of Gastroenterology·Etsuko HashimotoKeiko Shiratori
Feb 5, 2009·Kidney International·Renée de MutsertFriedo W Dekker
Feb 13, 2009·American Journal of Epidemiology·David B Richardson, Jay S Kaufman
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sean F AltekruseMarsha E Reichman
Feb 28, 2009·Gastroenterology·James E Everhart, Constance E Ruhl

❮ Previous
Next ❯

Citations

Dec 29, 2010·Journal of Oncology·Fatima RangwalaAnna Mae Diehl
Dec 29, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yusuke KawamuraHiromitsu Kumada
Nov 28, 2013·Clinics in Liver Disease·Ester Vanni, Elisabetta Bugianesi
Aug 21, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Geoffrey Farrell
May 15, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rohit LoombaUNKNOWN REVEAL–HBV Study Group
Dec 4, 2015·International Journal of Environmental Research and Public Health·Meaghan A LabineGerald Y Minuk
Jan 8, 2016·Alimentary Pharmacology & Therapeutics·S Singh, R Loomba
Oct 30, 2012·Clinics in Liver Disease·Priya Grewal, Vijay Anand Viswanathen
Mar 8, 2011·Current Problems in Surgery·William P SchecterJohn E Scarborough
Jul 23, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Quangui SunChunxu Hai
Aug 15, 2012·Immunological Reviews·Amy R JohnsonLiza Makowski
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Jul 3, 2015·Cancer Causes & Control : CCC·Shu-Chun ChuangMia Hashibe
Mar 27, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yi ChenJianjun Luo
Jul 5, 2016·Clinics in Liver Disease·Kartik JoshiRobert Gish
Oct 4, 2016·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Ángel BreaUNKNOWN Grupo de trabajo sobre Dislipemia Aterogénica, Sociedad Española de Arteriosclerosis
Nov 23, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fredrik ÅbergAntti Jula
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Richard ParkerBin Gao
Aug 16, 2012·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
May 11, 2017·World Journal of Gastroenterology : WJG·Ayako Iida-UenoNorifumi Kawada
Nov 20, 2019·Clinical Science·Marta B AfonsoCecília M P Rodrigues
Dec 20, 2019·Alcoholism, Clinical and Experimental Research·Fredrik ÅbergVille Männistö
Mar 25, 2020·World Journal of Gastroenterology : WJG·Murali GanesanNatalia A Osna
Sep 26, 2020·Frontiers in Medicine·Francisco IdalsoagaJuan Pablo Arab
Oct 31, 2013·The International Journal of Biological Markers·Yuanyuan ZhangXiaowen Chen
Jan 10, 2021·International Journal of Molecular Sciences·Vijay PandyarajanJu Dong Yang
Jul 31, 2021·World Journal of Gastroenterology : WJG·María B PisanoPamela Valva
Aug 3, 2021·Journal of Hepatology·Naomi F LangeJean-François Dufour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Takamasa OhkiMasao Omata
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Mustafa S AschaNizar N Zein
© 2021 Meta ULC. All rights reserved