Obesity and androgens: facts and perspectives

Fertility and Sterility
R Pasquali

Abstract

This review discusses androgen status in male and female obesity, according to their specific phenotype, and the main mechanisms responsible. Published data in the literature of the last 20 years represented the basis of most of the data and concepts incorporated in the review. Obesity is associated with profound alterations in androgen secretion, transport, metabolism, and action, according to a dichotomous behavior depending on sex. Obese men are characterized by a progressive decrease of testosterone levels with increasing body weight, whereas obese women, particularly those with the abdominal phenotype, tend to develop a condition of functional hyperandrogenism. Reduced sex hormone-binding globulin synthesis and circulating blood levels represent the sole common mechanism which is responsible in both sexes. Among other still partially undefined factors, mechanisms potentially responsible for the sex dichotomy in androgen levels involve specific alterations of gonadotropin secretion, estrogens, the hypothalamic-pituitary-adrenal axis, leptin, androgen receptors, specific steroidogenic enzymes in the peripheral tissues, and, possibly, ghrelin. In both sexes, androgens play an important role in determining the sex-dependent pa...Continue Reading

References

Sep 1, 1992·Annals of Epidemiology·K T Khaw, E Barrett-Connor
Dec 1, 1991·Metabolism: Clinical and Experimental·J HaarboC Christiansen
Feb 24, 1990·Lancet·P M StewartC R Edwards
Jan 1, 1991·Metabolism: Clinical and Experimental·R PasqualiL Bortoluzzi
May 1, 1990·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R PasqualiM Capelli
Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·M A KirschnerN Ertel
Jan 1, 1989·The Medical Clinics of North America·A R Glass
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·S R PlymateK E Friedl
May 1, 1986·Clinics in Endocrinology and Metabolism·J A Miller, H S Jacobs
May 1, 1988·The Journal of Clinical Endocrinology and Metabolism·G W StrainR S Rosenfeld
Mar 3, 1988·The New England Journal of Medicine·T J McKenna
Mar 1, 1988·Journal of Endocrinological Investigation·R PasqualiL Barbara
Oct 1, 1985·European Journal of Clinical Investigation·M Rebuffé-ScriveP Björntorp
Dec 1, 1969·The Journal of Clinical Investigation·C LongcopeR Horton
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·D J EvansA H Kissebah
Nov 1, 1984·The Journal of Clinical Endocrinology and Metabolism·E SamojlikN H Ertel
Sep 1, 1982·Metabolism: Clinical and Experimental·G W StrainD K Fukushima
May 1, 1983·The Journal of Clinical Endocrinology and Metabolism·J SchneiderJ Fishman
Jan 1, 1981·The International Journal of Biochemistry·A Cryer
Oct 1, 1981·The Journal of Clinical Endocrinology and Metabolism·S StanikS G Korenman
Apr 1, 1995·Metabolism: Clinical and Experimental·A TchernofF Labrie
Apr 1, 1995·Metabolism: Clinical and Experimental·E Diamanti-KandarakisS Raptis
Jun 1, 1995·European Journal of Endocrinology·J BornH L Fehm
Jan 5, 1995·Biochemical and Biophysical Research Communications·R PecqueryY Giudicelli
Feb 1, 1995·The Journal of Clinical Endocrinology and Metabolism·R PasqualiV Vicennati
Jan 1, 1994·Brain Research Bulletin·D M BlankM S Blank
Oct 20, 1994·The New England Journal of Medicine·E P SmithK S Korach
Jun 1, 1994·The Journal of Clinical Endocrinology and Metabolism·R LeenenH P Koppeschaar

❮ Previous
Next ❯

Citations

Mar 24, 2010·Archives of Gynecology and Obstetrics·Alexandros DafopoulosGeorgios Maroulis
May 30, 2008·Breast Cancer Research and Treatment·Laura BagliettoGraham G Giles
Sep 10, 2010·Cancer Causes & Control : CCC·Fiona ChionhGraham G Giles
Apr 2, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xiaoli ChenYuhong Huang
Oct 8, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R PasqualiU Pagotto
Mar 3, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S C HoA Sham
Aug 31, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K J McInnesE R Simpson
Nov 5, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Manuel Tena-Sempere
Jul 23, 2009·Obstetrics and Gynecology·Jennifer KellerAbhimanyu Garg
Oct 14, 2011·Cornea·Arie Y NemetIgor Kaiserman
Jan 5, 2007·Clinical and Experimental Pharmacology & Physiology·Michael I TrenellNaomi L Rogers
Dec 24, 2010·Reproductive Biology and Endocrinology : RB&E·Mervat M El-EshmawyAmany K El Hawary
Aug 19, 2011·Reproductive Health·Linn Berger HåkonsenCecilia Høst Ramlau-Hansen
Oct 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Bulent O YildizRicardo Azziz
Aug 31, 2012·The Journal of Clinical Endocrinology and Metabolism·Miriam A BredellaKaren K Miller
Nov 26, 2013·European Journal of Endocrinology·Renato Pasquali, Alessandra Gambineri
Apr 23, 2013·European Journal of Nutrition·Therese KarlssonIngrid Larsson
Feb 4, 2014·Animal Reproduction Science·Laura BoudreauKirsti Rouvinen-Watt
Jul 23, 2014·European Journal of Endocrinology·Gerard ConwayUNKNOWN ESE PCOS Special Interest Group
May 23, 2014·European Journal of Endocrinology·Gerard ConwayUNKNOWN ESE PCOS Special Interest Group
Mar 2, 2010·Women's Health·Lisa J MoranHelena J Teede
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Israel Pérez-TorresGuadalupe Baños
Jan 28, 2009·The Journal of Sexual Medicine·Johanna L HannanMichael A Adams
Apr 9, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Eduardo Alejandro MormandiOscar Levalle
Nov 28, 2012·Obstetrics and Gynecology Clinics of North America·Mamie McLean, Melissa F Wellons
May 15, 2007·The Journal of Sexual Medicine·Wael ZohdyYasser Ibrahim
Mar 9, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Magdalena Olszanecka-GlinianowiczPiotr Skałba
Dec 24, 2011·Fertility and Sterility·Kathleen M Hoeger, Sharon E Oberfield
Sep 6, 2011·Brain Research·Monica L AndersenSergio Tufik

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Madhavi PusalkarAnurupa Maitra
The Journal of Clinical Endocrinology and Metabolism
M A KirschnerN Ertel
Journal of Andrology
Ahmad O HammoudDouglas T Carrell
© 2022 Meta ULC. All rights reserved