Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Soo Ji LeeJoohon Sung

Abstract

Epidemiologic studies have replicated positive associations between obesity and bone health, but their mechanisms are still debatable. We aimed to scrutinize an association between bone health and obesity using genetic instrumental variables (IVs) with the distinction of general versus abdominal obesity. We selected independent IVs of body mass index (BMI) and BMI-adjusted waist circumference (aWC, a proxy of a central fat distribution) by combining novel genomewide searches from the Korean Genome Epidemiology Study (KoGES) consortium and existing reports. We evaluated the associations of obesity indices with bone health measures for weight-bearing and non-weight-bearing bones, applying standard Mendelian randomization analyses. The IVs for BMI and aWC selected from KoGES cohort studies (n = 14,389) explained its own trait only, negating the mutual correlation at the phenotypic level. Two-stage least squares analyses using an independent cohort study (n = 2507, mean age = 44.4 years, men = 44.3%) showed that BMI but not aWC was positively associated with bone mineral density (BMD for weight-bearing bones: 0.063 ± 0.016 g/cm2 per one standard deviation increase in BMI), implying the fat distribution might be neutral. The associa...Continue Reading

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Citations

Jun 10, 2020·International Journal of Environmental Research and Public Health·Deepti K SharmaPeter M Clifton
Sep 9, 2020·Current Osteoporosis Reports·M A ChristouD Karasik
Dec 12, 2019·Frontiers in Endocrinology·Jie ZhengJonathan H Tobias
Nov 4, 2020·Diagnostics·Md Tawkat Islam KhondakerTanvir Alam
Aug 29, 2020·Mechanisms of Ageing and Development·Napatsorn ImerbSiriporn C Chattipakorn
Oct 29, 2020·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Marise CrivelliFlávia F Bezerra
Oct 6, 2021·Climacteric : the Journal of the International Menopause Society·J ZandonáM C O Wender

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Methods Mentioned

BETA
genotyping

Software Mentioned

SOLAR Eclipse
STATA

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