Obesity and brain inflammation: a focus on multiple sclerosis

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
F PalavraF Reis

Abstract

The increase in prevalence of obesity in industrialized societies is an indisputable fact. However, the apparent passive role played by adipocytes, in pathophysiological terms, has been gradually substituted by a metabolically active performance, relevant to many biochemical mechanisms that may contribute to a chronic low-grade inflammatory status, which increasingly imposes itself as a key feature of obesity. This chronic inflammatory status will have to be integrated into the complex equation of many diseases in which inflammation plays a crucial role. Multiple sclerosis (MS) is a chronic inflammatory condition typically confined to the central nervous system, and many work has been produced to find possible points of contact between the biology of this immune-mediated disease and obesity. So far, clinical data are not conclusive, but many biochemical features have been recently disclosed. Brain inflammation has been implicated in some of the mechanisms that lead to obesity, which has also been recognized as an important player in inducing some degree of immune dysfunction. In this review, we collected evidence that allows establishing bridges between obesity and MS. After considering epidemiological controversies, we will fo...Continue Reading

References

May 1, 1985·Journal of the Neurological Sciences·A SenaG Rebel
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·J M Lemire
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SteinbrecherS Brocke
Jun 12, 2003·Journal of Neuroimmunology·Anna Paola BatocchiMassimiliano Mirabella
Jul 17, 2003·Journal of Neurology·Armando SenaM Graça Morais
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sammy BedouiTakashi Yamamura
Dec 12, 2003·Archives of Physical Medicine and Rehabilitation·Jennifer N SlawtaGail Anderson
Jan 31, 2004·Seminars in Immunology·Kiyoshi Takeda, Shizuo Akira
Aug 4, 2004·Lancet·Armando SenaM Graça Morais
Aug 4, 2004·Lancet·Marie-Laure Laroche, Louis Merle
Mar 12, 2005·Obesity Research·José B C CarvalheiraMario J A Saad
Mar 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe MatareseSerafino Zappacosta
Aug 17, 2005·Current Drug Targets. CNS and Neurological Disorders·E C LealA F Ambrósio
Dec 13, 2005·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Jan 6, 2006·The Journal of Clinical Investigation·Jaap G Neels, Jerrold M Olefsky
May 12, 2006·Neurological Research·Alireza MinagarJ Steven Alexander
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Mar 14, 2007·Neurochemistry International·Ana Rita AlvaroCláudia Cavadas
Oct 17, 2007·Annual Review of Physiology·Martin G MyersHeike Münzberg
Jan 29, 2008·Recent Patents on CNS Drug Discovery·Sara XapelliJoão O Malva
Feb 19, 2008·The Journal of Biological Chemistry·Janice M ZabolotnyBarbara B Kahn
Feb 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Jennifer W HillCarol F Elias
Mar 12, 2008·Journal of Neurochemistry·Ana Rita AlvaroCláudia Cavadas
Apr 26, 2008·Neuroepidemiology·Norrina B AllenMichael H Alderman
Jul 25, 2008·Nature·Ruslan Medzhitov
Aug 6, 2008·Journal of Leukocyte Biology·Laura PiccioAnne H Cross
Oct 11, 2008·Multiple Sclerosis : Clinical and Laboratory Research·Ra MarrieT Vollmer
Jan 27, 2009·American Journal of Physical Medicine & Rehabilitation·Seema R KhuranaJodie K Haselkorn

❮ Previous
Next ❯

Citations

Oct 11, 2016·Mediators of Inflammation·José de Jesús Guerrero-GarcíaDaniel Ortuño-Sahagún
Dec 17, 2017·Journal of Child Neurology·Erin YamamotoManikum Moodley
Jun 1, 2019·Journal of Magnetic Resonance Imaging : JMRI·Melissa SchallN Jon Shah
Jan 9, 2019·Frontiers in Neuroscience·Peter Van Dyken, Baptiste Lacoste
Mar 6, 2019·International Journal of MS Care·Lacey BromleyAndrew D Ray
Jul 10, 2020·Multiple Sclerosis and Related Disorders·Rasha M FahmiTakwa H M Elkhatib
Apr 3, 2021·Multiple Sclerosis and Related Disorders·Duong T ChuTanuja Chitnis
May 6, 2021·International Journal of Molecular Sciences·Gopi BattineniSeyed Khosrow Tayebati
Jul 22, 2021·Neurology. Neuroimmunology and Neuroinflammation·Pauline MillesUNKNOWN KidBiosep

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Radhika Gade-AndavoluLawrence A Cone
© 2022 Meta ULC. All rights reserved