Obesity and bronchodilator response in black and Hispanic children and adolescents with asthma

Chest
Meghan E McGarryEsteban G Burchard

Abstract

Obesity is associated with poor asthma control, increased asthma morbidity, and decreased response to inhaled corticosteroids. We hypothesized that obesity would be associated with decreased bronchodilator responsiveness in children and adolescents with asthma. In addition, we hypothesized that subjects who were obese and unresponsive to bronchodilator would have worse asthma control and would require more asthma controller medications. In the Study of African Americans, Asthma, Genes, and Environments (SAGE II) and the Genes-environments and Admixture in Latino Americans (GALA II) study, two identical, parallel, case-control studies of asthma, we examined the association between obesity and bronchodilator response in 2,963 black and Latino subjects enrolled from 2008 to 2013 using multivariable logistic regression. Using bronchodilator responsiveness, we compared asthma symptoms, controller medication usage, and asthma exacerbations between nonobese (< 95th% BMI) and obese (≥ 95th% BMI) subjects. The odds of being bronchodilator unresponsive were 24% (OR, 1.24; 95% CI, 1.03-1.49) higher among obese children and adolescents compared with their not obese counterparts after adjustment for age, race/ethnicity, sex, recruitment sit...Continue Reading

References

Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Feb 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·E F JuniperM Townsend
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·I Tillie-LeblondP Gosset
Nov 7, 1999·The Journal of Allergy and Clinical Immunology·P LozanoK B Weiss
Aug 8, 2002·Pediatrics·Lara J Akinbami, Kenneth C Schoendorf
Dec 4, 2003·Thorax·K G TantisiraUNKNOWN Childhood Asthma Management Program Research Group
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Jan 24, 2006·Archives of Disease in Childhood·V Flaherman, G W Rutherford
Sep 8, 2006·Social Science & Medicine·Glorisa CaninoMargarita Alegría
Jan 20, 2007·American Journal of Respiratory and Critical Care Medicine·David A Beuther, E Rand Sutherland
Nov 19, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Shawn D AaronUNKNOWN Canadian Respiratory Clinical Research Consortium
Jun 25, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Adit A GindeCarlos A Camargo
Nov 7, 2009·American Journal of Respiratory and Critical Care Medicine·Wendy C MooreUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Nov 26, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Peter H MichelsonAmber E Barnato
Jan 19, 2010·Pediatric Pulmonology·James L PuckettSteven C George
Jan 27, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Carlos A CamargoThomas J Ferro
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Erick FornoUNKNOWN Childhood Asthma Management Program Research Group
Aug 9, 2011·The Journal of Allergy and Clinical Immunology·Kenneth B QuintoSandra C Christiansen
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Apr 4, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William J Anderson, Brian J Lipworth
Jan 3, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L-P Boulet
Feb 9, 2013·American Journal of Respiratory and Critical Care Medicine·Luisa N BorrellEsteban G Burchard
Dec 10, 2013·The Journal of Allergy and Clinical Immunology·Michael SchatzTmirah Haselkorn
May 3, 2014·Annals of the American Thoracic Society·Deepa RastogiCarmen R Isasi
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Jason E LangJohn J Lima

❮ Previous
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Citations

Oct 3, 2015·Expert Review of Clinical Pharmacology·Charlotte Suppli Ulrik
Feb 10, 2016·Current Opinion in Allergy and Clinical Immunology·Cullen M DutmerAndrew H Liu
Mar 26, 2016·Hospital Pediatrics·Elena AragonaDinesh K Pillai
Dec 29, 2016·Current Opinion in Allergy and Clinical Immunology·Erick Forno, Juan C Celedón
May 10, 2017·The Journal of Allergy and Clinical Immunology·Deepa RastogiJohn M Greally
Mar 13, 2018·Expert Opinion on Drug Metabolism & Toxicology·Mario CazzolaPaola Rogliani
Nov 22, 2017·Annals of the American Thoracic Society·Deepa Rastogi, Fernando Holguin
Aug 31, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sarah OrfanosReynold A Panettieri
Aug 30, 2018·Hospital Pediatrics·Elissa GrossDeepa Rastogi
Sep 3, 2016·The European Respiratory Journal·Fariba AhmadizarAnke H Maitland-van der Zee
Sep 12, 2019·Current Allergy and Asthma Reports·Arjun MohanNjira Lugogo
May 23, 2020·Obesity·Barbara Ameer, Michael A Weintraub
Jun 9, 2020·Expert Review of Respiratory Medicine·Angelica TiotiuFulvio Braido
Apr 8, 2020·American Journal of Respiratory and Critical Care Medicine·Deepa RastogiJohn M Greally
Mar 26, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Toni A M TobiasDeepa Rastogi
Dec 15, 2016·Asthma Research and Practice·Cottini Marcello, Lombardi Carlo
Nov 8, 2018·Nutrients·Lorenza Di GenovaSusanna Esposito
Dec 20, 2019·Expert Review of Respiratory Medicine·Meghan Althoff, Fernando Holguin
Aug 1, 2020·Journal of the National Medical Association·Rebecca N JeromeConsuelo H Wilkins
Feb 21, 2021·Asthma Research and Practice·A CorlateanuN Siafakas
Apr 8, 2020·Paediatric Respiratory Reviews·Laura ChenDeepa Rastogi
Mar 7, 2021·Children·Emanuela di PalmoAndrea Pession
Mar 12, 2021·Journal of Asthma and Allergy·Matthew McCravyLoretta G Que
Apr 9, 2018·The Journal of Allergy and Clinical Immunology·Ubong PetersErick Forno
May 3, 2019·Respiratory Medicine·Mario CazzolaMaria Gabriella Matera
Jul 30, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Li HuangYungling L Lee
Aug 8, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kathryn E KylerChristine L Schuler
Sep 1, 2021·Pilot and Feasibility Studies·Christine L M JosephChristine Cole Johnson
Dec 23, 2019·Revue des maladies respiratoires·C GuguenJ-M Perotin
Oct 18, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Tara F CarrFernando D Martinez
Oct 25, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Anne M FitzpatrickJocelyn R Grunwell
Oct 15, 2021·Journal of Applied Physiology·Swati A BhatawadekarJason H T Bates

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