Obesity and cardiovascular diseases-theoretical background and therapeutic consequences

Zeitschrift für Kardiologie
Heinz VöllerB Bjarnason-Wehrens

Abstract

In the normal population, the prevalence of obesity is almost 20%. It is a condition influenced by genetic factors, so that individual behavior cannot be regarded as its sole cause. The amount of food is essentially determined by the hormone leptin, the feedback regulation of which can be disturbed by a modification of the molecule or a mutation of the receptor. A further important determinant is energy consumption, which is subject to large individual variations, which partly result from thermogenesis. With regard to the fat distribution, it is concentrated on the trunk in the android form as compared to the hips in the gynecoid form. The android form is subject to a higher incidence of cardiovascular morbidity and mortality. The indirect determination of body fat by measuring the body mass index (weight [kg]/body weight [m(2)]) is hence less reliable than measuring the waist (women > 80 cm, men > 94 cm). The effects of generalized obesity on cardiovascular function are chiefly an increase of blood volume and an eccentric left ventricular hypertrophy. This first of all results in diastolic dysfunction, which can give rise to a disturbance of systolic function in left ventricular dilatation. Concentric hypertrophy develops in t...Continue Reading

Citations

Jan 2, 2013·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Nasser M Rizk, Mervat Yousef
Jul 12, 2011·Cardiovascular Toxicology·Sherma ZibadiDouglas F Larson

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