Obesity and coronary artery calcification: Can it explain the obesity-paradox?

The International Journal of Cardiovascular Imaging
Ahmed AljizeeriBenjamin J W Chow

Abstract

The inverse relationship between obesity and adverse cardiovascular outcomes has been coined the 'obesity-paradox'. We sought to determine the relationship between measures of obesity [body mass index (BMI), body surface area (BSA) and body fat percentage (BF%)] and coronary artery calcification (CAC). We retrospectively analyzed patients who underwent CAC using the Agatston score. Baseline demographics were collected and BMI, BSA and BF% were calculated. A two-stage regression modeling approach was used to evaluate the association between BMI, BSA, BF% and Agatston score. Of the 6661 patients [mean age = 57.1 ± 10.8 years, men = 54.3%, median Agatston score = 14 (0, 163)], 0.1% were underweight, 21.3% had normal BMI, 39.1% were overweight and 39.4% were obese. The mean BMI, BSA and BF% were 29.6 ± 6.1 kg/m(2), 1.97 ± 0.25 m(2) and 37 ± 10 %, respectively. There was an independent association between the presence of CAC and BMI (5 kg/m(2) increments) (OR 1.05, CI 1.00-1.11, P = 0.038) and BF% (OR 2.38, CI 1.05-5.41, P = 0.038). Neither BMI categories nor large BSA independently predicted the presence of CAC. BF% predicted the extent of CAC in men but not in women, and higher BF% was associated with higher category of CAC severi...Continue Reading

References

Mar 1, 1991·The British Journal of Nutrition·P DeurenbergJ C Seidell
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Aug 1, 1995·American Heart Journal·J DuflouJ Smialek
Oct 7, 1998·Circulation·R M KraussS M Grundy
Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
Apr 15, 2000·Nature·P G Kopelman
Aug 31, 2001·Journal of the American College of Cardiology·T B HorwichJ H Tillisch
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Katherine M FlegalClifford L Johnson
Apr 2, 2003·The American Journal of Cardiology·Carl J LavieMandeep R Mehra
Oct 29, 2003·Circulation·Tomasz MazurekYi Shi
Nov 16, 2005·Atherosclerosis·Demosthenes B PanagiotakosChristodoulos Stefanadis
Jul 13, 2007·European Heart Journal·Abel Romero-CorralFrancisco Lopez-Jimenez
Feb 20, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Romero-CorralF Lopez-Jimenez
Jul 1, 2008·American Heart Journal·Antigone OreopoulosFinlay A McAlister
Aug 21, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K J Rothman
May 23, 2009·Journal of the American College of Cardiology·Carl J LavieHector O Ventura
Aug 18, 2009·The American Journal of Medicine·Carl J LavieHector O Ventura
Dec 25, 2009·Atherosclerosis·Nikolaos AlexopoulosPaolo Raggi
Dec 3, 2010·The New England Journal of Medicine·Amy Berrington de GonzalezMichael J Thun
Dec 14, 2011·Coronary Artery Disease·Sion K RoyMatthew J Budoff
Sep 6, 2012·Circulation·Jean-Pierre Després
Mar 14, 2014·JACC. Heart Failure·Carl J LavieHector O Ventura

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Citations

Apr 27, 2019·Nutrition and Cancer·Roya TalebanZiba Farajzadegan
Aug 28, 2020·Current Problems in Cardiology·Natraj KattaMartin A Alpert
Aug 25, 2021·BMC Psychiatry·Trine TrabRené Ernst Nielsen

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