Obesity and depressive symptoms in mid-life: a population-based cohort study

BMC Psychiatry
Anwar MulugetaE Hyppönen

Abstract

Obesity and depression are both highly prevalent public health disorders and evidence on their relationship is inconsistent. This study examined whether depressive symptoms are associated with current obesity, and further, whether obesity in turn is associated with an increased odds of depressive symptoms five years later after accounting for potential lifestyle confounders and depressive symptoms at baseline. Data were obtained from the 1958 British birth cohort (N = 9217 for cross-sectional and 7340 for prospective analysis). Clinical Interview Schedule-Revised and Mental Health Inventory-5 were used for screening depressive symptoms at ages 45 and 50 years, respectively. General and central obesity were defined using measurements of body mass index (BMI) and waist circumference (WC) at 45 years, respectively. There was a cross-sectional association between depressive symptoms and obesity: participants with ≥2 depressive symptoms had 31% (95%CI 11% to 55%) higher odds of general and 26% higher odds of central obesity (95%CI 8% to 47%). In prospective analyses, both general and central obesity were associated with higher odds of depressive symptoms five years later among women but not in men (Pinteraction < 0.01). After adjust...Continue Reading

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Citations

Jun 9, 2020·Experimental and Therapeutic Medicine·Amorin Remus PopaSebastian Nemeth
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Jun 11, 2019·Journal of Affective Disorders·Rodrigo B MansurRoger S McIntyre
Feb 9, 2020·Journal of Psychosomatic Research·Joane MattaSebastien Czernichow

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