Obesity and high blood pressure: a clinical phenotype for the insulin resistance syndrome in African Americans.

The Journal of Clinical Hypertension
Kimberly L CampbellBonita Falkner

Abstract

The high prevalence of insulin resistance syndrome in African Americans predisposes this population to higher morbidity and mortality from cardiovascular disease. To test the hypothesis that the combination of obesity and high blood pressure (BP) represents the physical phenotype of insulin resistance syndrome, 337 African-American men and women aged 32+/-4 years were examined and classified into four groups (nonobese-normal BP, nonobese-high BP, obese-normal BP, obese-high BP), according to presence or absence of obesity and high BP. Mean values of glucose, insulin, lipids, urinary albumin excretion, and clamp-derived insulin sensitivity were determined for each group. Prevalence of prediabetes (24.4%), diabetes (19.2%), and insulin resistance syndrome (87.2%) were highest in the obese-high BP group (p<0.001). Mean triglycerides, urinary albumin excretion, fasting glucose, fasting insulin, and insulin resistance were highest in the obese-high BP group (p<0.001). Subjects with both obesity and high BP showed greater expression of lipid and glucose abnormalities, higher urinary albumin excretion, and greater prevalence of prediabetes, undetected type 2 diabetes, and insulin resistance syndrome.

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Citations

Mar 29, 2008·Metabolic Syndrome and Related Disorders·Craig ChangGloria Lena Vega
Apr 24, 2008·The Journal of Clinical Investigation·Kumar SharmaBarry J Goldstein
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Feb 22, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kumiko TaguchiTsuneo Kobayashi

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