Obesity and laboratory aspirin resistance in high-risk pregnant women treated with low-dose aspirin

American Journal of Obstetrics and Gynecology
Matthew M FinneranKara M Rood

Abstract

Low-dose aspirin is used for preeclampsia prevention in high-risk women, but the precise mechanism and optimal dose are unknown. Evidence suggests that an imbalance in prostacyclin and thromboxane A2 (TXA2) plays a key role in the pathogenesis of preeclampsia. Aspirin has a dose-dependent effect blocking production of TXA2, a potent stimulator of platelet aggregation and promoter of vasoconstriction. Incomplete inhibition of platelet aggregation, designated aspirin resistance, can be reduced by increasing the aspirin dose. Evidence in the nonobstetric literature suggests that aspirin resistance may be more common among patients with a high body mass index. To investigate the association of obesity on platelet-derived thromboxane inhibition in high-risk women treated with low-dose aspirin. This was a secondary analysis of a prospective multi-centered study investigating the effect of low-dose aspirin (60-mg) administration in women at high risk for preeclampsia. Maternal serum TXB2 (an indirect measure of TxA2) levels were drawn at 3 time points: randomization (13-26 weeks' gestation), second trimester (at least 2 weeks after randomization and 24-28 weeks' gestation), and third trimester (34-38 weeks' gestation). Patients were i...Continue Reading

Citations

Nov 7, 2019·The Cochrane Database of Systematic Reviews·Lelia DuleyLisa M Askie
Mar 3, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tanja Premru-SrsenIvan Verdenik
Mar 14, 2020·Current Hypertension Reports·Laura SanapoGhada Bourjeily
May 22, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ramesh AraganjiShivaprasad S Goudar
Jul 3, 2021·International Journal of Molecular Sciences·Scott W Walsh, Jerome F Strauss
Aug 15, 2021·American Journal of Obstetrics and Gynecology·Li LinHuixia Yang
Dec 3, 2021·American Journal of Perinatology·Stephen E GeeKara M Rood

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