Obesity and post-operative cognitive dysfunction: a systematic review and meta-analysis

Diabetes/metabolism Research and Reviews
Insa FeinkohlTobias Pischon

Abstract

Post-operative cognitive dysfunction, a condition distinct from post-operative delirium (POD), occurs frequently after surgery, and is related to dementia and premature death. Obesity increases the risk of late-life cognitive impairment, but little is known about its role in post-operative cognitive dysfunction. We conducted a systematic review and meta-analysis of studies on the association between obesity and risk of post-operative cognitive dysfunction. PubMed and the Cochrane Library were systematically searched. Studies were included if they had prospective designs, reported on human adults undergoing surgery, if cognitive function was measured pre- and post-surgery, if obesity, body mass index (BMI) and/or body weight were ascertained, and if associations with post-operative cognitive dysfunction were reported as relative risks or odds ratios. Underweight, weight loss, and post-operative delirium were not considered. Inclusion criteria were met by six articles. Samples totaled 1432 older patients (mean age ≥62 years) who were followed up for 24 h to 12 months after surgery. Analysis of studies with obesity defined as a categorical measure found a non-significantly higher risk of post-operative cognitive dysfunction among ...Continue Reading

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Citations

Jun 13, 2017·Clinical Practice and Epidemiology in Mental Health : CP & EMH·I FeinkohlT Pischon
Feb 23, 2019·Journal of Nutrition in Gerontology and Geriatrics·Robert M RothJohn A Batsis
Jan 7, 2020·The British Journal of Surgery·M CarronM Foletto
Sep 3, 2019·Journal of Alzheimer's Disease : JAD·Patrick J SmithJames A Blumenthal
Mar 18, 2017·Deutsches Ärzteblatt International·Insa FeinkohlTobias Pischon
Oct 17, 2018·Dementia and Geriatric Cognitive Disorders·Gunnar LachmannTobias Pischon

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