Obesity and related conditions and risk of inflammatory breast cancer: a nested case-control study.

Breast Cancer Research and Treatment
Catherine SchairerLawrence H Kushi

Abstract

Inflammatory breast cancer (IBC) is a rare, poorly understood and aggressive tumor. We extended prior findings linking high body mass index (BMI) to substantial increased IBC risk by examining BMI associations before and after adjustment for well-characterized comorbidities using medical record data for diabetes, insulin resistance, and disturbances of cholesterol metabolism in a general community healthcare setting. We identified 247 incident IBC cases diagnosed at Kaiser Permanente Northern California between 2005 and 2017 and 2470 controls matched 10:1 on birth year and geographic area and with ≥ 13 months of continuous enrollment prior to diagnosis/index date. We assessed exposures from 6 years up to one year prior to the diagnosis/index date, using logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs). Before adjustment for comorbidities, ORs (95% CIs) for BMI of 25-< 30, 30-< 35, and ≥ 35 compared to < 25 kg/m2 were 1.5 (0.9-2.3), 2.0 (1.2-3.1), and 2.5 (1.4-4.4), respectively. After adjustment for pre-diabetes/diabetes, HDL-C and triglyceride levels, and dyslipidemia, corresponding ORs were 1.3 (0.8-2.1), 1.6 (0.9-2.9), and 1.9 (1.0-3.5). The OR for HDL-C levels < 50 mg/dL compared to ≥ 6...Continue Reading

References

Dec 16, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S ChangS D Hursting
Jun 1, 2006·Breast Disease·William F AndersonPaul H Levine
Nov 7, 2008·International Journal of Cancer. Journal International Du Cancer·Reiko SuzukiAlicja Wolk
Jan 28, 2012·Nature·Harold Varmus, Ed Harlow
Nov 6, 2012·European Journal of Nutrition·Peter BoylePhilippe Autier
Feb 15, 2013·Cancer Causes & Control : CCC·Philippe AutierPeter Boyle
Apr 11, 2013·Menopause : the Journal of the North American Menopause Society·Katherine EspositoDario Giugliano
Sep 21, 2013·Journal of the National Cancer Institute·Laleh Amiri-KordestaniJo Anne Zujewski
Sep 21, 2013·Journal of the National Cancer Institute·Catherine SchairerDiana L Miglioretti
Sep 12, 2014·Diabetologia·Yi HuangYuli Huang
Jun 11, 2015·Drugs·Ulrike HostalekSteven Hildemann
Jul 16, 2015·The British Journal of Nutrition·Mathilde TouvierPaule Latino-Martel
Jan 23, 2016·Cancer Causes & Control : CCC·Rachel L AtkinsonAbenaa M Brewster
Jun 25, 2016·International Journal of Molecular Sciences·Shawna B Matthews, Henry J Thompson
Jul 19, 2016·Current Opinion in Pharmacology·Ryan KolbWeizhou Zhang
Jan 4, 2017·Endocrine·Lorenzo ScappaticcioKatherine Esposito
Jan 15, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Catherine SchairerEric A Engels
Jun 14, 2017·Mediators of Inflammation·Riley J MorrowMatthias Ernst
Nov 16, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Gagan Priya, Sanjay Kalra
Feb 17, 2018·Breast Cancer Research and Treatment·Catherine SchairerRuth M Pfeiffer
Mar 3, 2019·Breast Cancer Research : BCR·Laura Garcia-Estevez, Gema Moreno-Bueno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

Antibiotics and Chemotherapy
L Bevanger
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
S ChangS D Hursting
© 2021 Meta ULC. All rights reserved