Obesity and risk of biochemical failure for patients receiving salvage radiotherapy after prostatectomy

International Journal of Radiation Oncology, Biology, Physics
Christopher R KingDaniel S Kapp

Abstract

Obesity has been proposed as an independent risk factor for patients undergoing surgery or radiotherapy (RT) for prostate cancer. Using body mass index (BMI) as a measure of obesity, we tested its role as a risk factor for patients receiving salvage RT after prostatectomy. Rates of subsequent biochemical relapse were examined in 90 patients who underwent salvage RT between 1984 and 2004 for biochemical failure after radical prostatectomy. Median follow-up was 3.7 years. The BMI was tested as a continuous and categorical variable (stratified as <25, 25-<30, and >or=30 kg/m(2)). Univariate and multivariate proportional hazards regression analyses were performed for clinical, pathologic, and treatment factors associated with time to relapse after salvage RT. There were 40 biochemical failures after salvage RT with a median time to failure of 1.2 years. The BMI was not associated with adverse clinical, pathologic, or treatment factors. On multivariate analysis, obesity was independently significant (hazard ratio [HR], 1.2; p = 0.01), along with RT dose (HR, 0.7; p = 0.003) and pre-RT prostate-specific antigen level (HR, 1.2; p = 0.0003). This study is weakly suggestive that obesity may be a risk factor for salvage RT patients. Whet...Continue Reading

References

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Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Christopher R King, Daniel S Kapp
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Jason A EfstathiouAnthony L Zietman

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Citations

Aug 24, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·B PichonM A Mahé
Aug 4, 2012·International Journal of Radiation Oncology, Biology, Physics·Wayne M ButlerBrian C Murray
Apr 26, 2011·International Journal of Radiation Oncology, Biology, Physics·Hans GeinitzCarsten Nieder
Sep 25, 2010·International Journal of Radiation Oncology, Biology, Physics·Hans GeinitzCarsten Nieder
Mar 11, 2021·Current Oncology Reports·Crystal S LanglaisStacey A Kenfield

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