Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study

Blood Advances
Marianna ThordardottirSigurdur Y Kristinsson

Abstract

All multiple myeloma (MM) cases are preceded by the premalignant state monoclonal gammopathy of undetermined significance (MGUS). Results from previous studies show a positive association between obesity and MM; however, the association between obesity and MGUS is controversial. The aims were to determine (1) if obesity is associated with an increased risk of MGUS and light-chain MGUS (LC-MGUS) and (2) whether obesity is associated with a higher risk of progression to MM and other lymphoproliferative (LP) diseases. Data from the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (N = 5764) were used. We performed serum protein electrophoresis and serum free light-chain assay on all subjects to identify MGUS and LC-MGUS cases. We included 11 different measures on current and previous obesity in our analysis. Logistic regression and Cox proportional-hazard regression were used to analyze the associations. A total of 300 (5.2%) MGUS and 275 (4.8%) LC-MGUS cases were identified. During a median follow-up of 8 years, 18 had progressed to MM and 11 to other LP diseases. We found no association between the 11 obesity markers and MGUS or LC-MGUS (odds ratios 0.81 to 1.15 for all 11 variables in both conditions). Inte...Continue Reading

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Citations

Apr 24, 2019·Blood·Tarek H MouhieddineIrene M Ghobrial
Nov 2, 2018·PloS One·Marianna ThordardottirSigurdur Y Kristinsson
May 21, 2020·Blood Advances·Molly WentRichard S Houlston
Sep 20, 2018·Current Osteoporosis Reports·Beatriz Gámez, Claire M Edwards
Jan 9, 2021·Annals of Hematology·Maira A Castaneda-AvilaMara Meyer Epstein
Feb 15, 2021·Clinical Lymphoma, Myeloma & Leukemia·Rebecca GeorgakopoulouMeletios-Athanasios Dimopoulos
Mar 7, 2020·Best Practice & Research. Clinical Haematology·Kylee MaclachlanDickran Kazandjian
Apr 13, 2021·Frontiers in Oncology·Vasileios LazarisKyriakos E Kypreos

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