Obesity and Sex Affect the Immune Responses to Tick-Borne Encephalitis Booster Vaccination.

Frontiers in Immunology
Erika Garner-SpitzerUrsula Wiedermann

Abstract

Obesity has dramatically increased over the last 30 years and reaches according to World Health Organization dimensions of a global epidemic. The obesity-associated chronic low-level inflammation contributes to severe comorbidities and directly affects many immune cells leading to immune dysfunction and increased susceptibility to infections. Thus, prophylaxis against vaccine-preventable diseases is crucial, yet the responsiveness to several vaccines is unclear under obesity. In order to assess the responsiveness to tick-borne encephalitis (TBE) vaccine, we revaccinated 37 obese individuals and 36 normal-weight controls with a licensed TBE vaccine. Metabolic, hormonal, and immunologic profiles along with vaccine-specific humoral and cellular immune responses were evaluated in sera and peripheral blood mononuclear cells (PBMCs) before, 1 week, 4 weeks, and 6 months after TBE booster. Obese adults had significantly increased metabolic (triglycerides, cholesterol ratios, leptin, insulin) and proinflammatory (C-reactive protein) parameters. They showed stronger initial increase of TBE-specific Ab titers (d7_d28) followed by a significantly faster decline after 6 months, which correlated with high body mass index and leptin and insu...Continue Reading

Associated Clinical Trials

Jul 12, 2019·Univ. Prof. Dr. Ursula Wiedermann

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Citations

Jan 29, 2021·Mediators of Inflammation·Feiyang CaiGuangjie Chen
Jul 17, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Annemarie J F WestheimRonit Shiri-Sverdlov
Apr 22, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ursula WiedermannAnthony J Good

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Methods Mentioned

BETA
FCS
FACS

Clinical Trials Mentioned

NCT04017052

Software Mentioned

FACS Diva
SPSS
GraphPad Prism
GraphPad

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